A direct test of the diathesis–stress model for depression

Colodro-Conde, L., Couvy-Duchesne, B., Zhu, G., Coventry, W. L., Byrne, E. M., Gordon, S., Wright, M. J., Montgomery, G. W., Madden, P. A. F., Ripke, S., Eaves, L. J., Heath, A. C., Wray, N. R., Medland, S. E. and Martin, N. G. (2017) A direct test of the diathesis–stress model for depression. Molecular Psychiatry, . doi:10.1038/mp.2017.130

Author Colodro-Conde, L.
Couvy-Duchesne, B.
Zhu, G.
Coventry, W. L.
Byrne, E. M.
Gordon, S.
Wright, M. J.
Montgomery, G. W.
Madden, P. A. F.
Ripke, S.
Eaves, L. J.
Heath, A. C.
Wray, N. R.
Medland, S. E.
Martin, N. G.
Title A direct test of the diathesis–stress model for depression
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1476-5578
Publication date 2017-07-11
Sub-type Article (original research)
DOI 10.1038/mp.2017.130
Open Access Status DOI
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract The diathesis–stress theory for depression states that the effects of stress on the depression risk are dependent on the diathesis or vulnerability, implying multiplicative interactive effects on the liability scale. We used polygenic risk scores for major depressive disorder (MDD) calculated from the results of the most recent analysis from the Psychiatric Genomics Consortium as a direct measure of the vulnerability for depression in a sample of 5221 individuals from 3083 families. In the same we also had measures of stressful life events and social support and a depression symptom score, as well as DSM-IV MDD diagnoses for most individuals. In order to estimate the variance in depression explained by the genetic vulnerability, the stressors and their interactions, we fitted linear mixed models controlling for relatedness for the whole sample as well as stratified by sex. We show a significant interaction of the polygenic risk scores with personal life events (0.12% of variance explained, P-value=0.0076) contributing positively to the risk of depression. Additionally, our results suggest possible differences in the aetiology of depression between women and men. In conclusion, our findings point to an extra risk for individuals with combined vulnerability and high number of reported personal life events beyond what would be expected from the additive contributions of these factors to the liability for depression, supporting the multiplicative diathesis–stress model for this disease.
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01 AA007535
R01 AA013326
R01 AA013321
R01 AA010249
R37 AA007728
Institutional Status UQ

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Created: Tue, 18 Jul 2017, 17:50:02 EST by Baptiste Couvy-duchesne on behalf of Institute for Molecular Bioscience