PREDICT-CP: study protocol of implementation of comprehensive surveillance to predict outcomes for school-aged children with cerebral palsy

Boyd, Roslyn N., Davies, Peter S. W., Ziviani, Jenny, Trost, Stewart, Barber, Lee, Ware, Robert, Rose, Stephen, Whittingham, Koa, Sakzewski, Leanne, Bell, Kristie, Carty, Christopher, Obst, Steven, Benfer, Katherine, Reedman, Sarah, Edwards, Priya, Kentish, Megan, Copeland, Lisa, Weir, Kelly, Davenport, Camilla, Brooks, Denise, Coulthard, Alan, Pelekanos, Rebecca, Guzzetta, Andrea, Fiori, Simona, Wynter, Meredith, Finn, Christine, Burgess, Andrea, Morris, Kym, Walsh, John, Lloyd, Owen, Whitty, Jennifer A. and Scuffham, Paul A. (2017) PREDICT-CP: study protocol of implementation of comprehensive surveillance to predict outcomes for school-aged children with cerebral palsy. BMJ Open, 7 7: e014950. doi:10.1136/bmjopen-2016-014950


Author Boyd, Roslyn N.
Davies, Peter S. W.
Ziviani, Jenny
Trost, Stewart
Barber, Lee
Ware, Robert
Rose, Stephen
Whittingham, Koa
Sakzewski, Leanne
Bell, Kristie
Carty, Christopher
Obst, Steven
Benfer, Katherine
Reedman, Sarah
Edwards, Priya
Kentish, Megan
Copeland, Lisa
Weir, Kelly
Davenport, Camilla
Brooks, Denise
Coulthard, Alan
Pelekanos, Rebecca
Guzzetta, Andrea
Fiori, Simona
Wynter, Meredith
Finn, Christine
Burgess, Andrea
Morris, Kym
Walsh, John
Lloyd, Owen
Whitty, Jennifer A.
Scuffham, Paul A.
Title PREDICT-CP: study protocol of implementation of comprehensive surveillance to predict outcomes for school-aged children with cerebral palsy
Journal name BMJ Open   Check publisher's open access policy
ISSN 2044-6055
Publication date 2017-07-01
Year available 2017
Sub-type Article (original research)
DOI 10.1136/bmjopen-2016-014950
Open Access Status DOI
Volume 7
Issue 7
Start page e014950
Total pages 20
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Abstract Objectives Cerebral palsy (CP) remains the world's most common childhood physical disability with total annual costs of care and lost well-being of $A3.87b. The PREDICT-CP (NHMRC 1077257 Partnership Project: Comprehensive surveillance to PREDICT outcomes for school age children with CP) study will investigate the influence of brain structure, body composition, dietary intake, oropharyngeal function, habitual physical activity, musculoskeletal development (hip status, bone health) and muscle performance on motor attainment, cognition, executive function, communication, participation, quality of life and related health resource use costs. The PREDICT-CP cohort provides further follow-up at 8-12 years of two overlapping preschool-age cohorts examined from 1.5 to 5 years (NHMRC 465128 motor and brain development; NHMRC 569605 growth, nutrition and physical activity).
Formatted abstract
Objectives: Cerebral palsy (CP) remains the world’s most common childhood physical disability with total annual costs of care and lost well-being of $A3.87b. The PREDICT-CP (NHMRC 1077257 Partnership Project: Comprehensive surveillance to PREDICT outcomes for school age children with CP) study will investigate the influence of brain structure, body composition, dietary intake, oropharyngeal function, habitual physical activity, musculoskeletal development (hip status, bone health) and muscle performance on motor attainment, cognition, executive function, communication, participation, quality of life and related health resource use costs. The PREDICT-CP cohort provides further follow-up at 8–12 years of two overlapping preschool-age cohorts examined from 1.5 to 5 years (NHMRC 465128 motor and brain development; NHMRC 569605 growth, nutrition and physical activity).

Methods and analyses: This population-based cohort study undertakes state-wide surveillance of 245 children with CP born in Queensland (birth years 2006–2009). Children will be classified for Gross Motor Function Classification System; Manual Ability Classification System, Communication Function Classification System and Eating and Drinking Ability Classification System. Outcomes include gross motor function, musculoskeletal development (hip displacement, spasticity, muscle contracture), upper limb function, communication difficulties, oropharyngeal dysphagia, dietary intake and body composition, participation, parent-reported and child-reported quality of life and medical and allied health resource use. These detailed phenotypical data will be compared with brain macrostructure and microstructure using 3 Tesla MRI (3T MRI). Relationships between brain lesion severity and outcomes will be analysed using multilevel mixed-effects models.

Ethics and dissemination: The PREDICT-CP protocol is a prospectively registered and ethically accepted study protocol. The study combines data at 1.5–5 then 8–12 years of direct clinical assessment to enable prediction of outcomes and healthcare needs essential for tailoring interventions (eg, rehabilitation, orthopaedic surgery and nutritional supplements) and the projected healthcare utilisation.

Trial registration number:
ACTRN: 12616001488493
Keyword Gross Motor Function
Quality-Of-Life
Function Classification-System
Medial Gastrocnemius-Muscle
Family Assessment Device
Colored-Progressive-Matrices
Pediatric Pain Questionnaire
Chronic Musculoskeletal Pain
Habitual Physical-Activity
Functional-Mobility-Scale
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 18 Jul 2017, 14:05:15 EST by Ms Leanne Sakzewski on behalf of School of Health & Rehabilitation Sciences