Evidence that eye-movement profiles do not explain slow binocular rivalry rate in bipolar disorder: support for a perceptual endophenotype

Law, Phillip C. F., Gurvich, Caroline T., Ngo, Trung T. and Miller, Steven M. (2017) Evidence that eye-movement profiles do not explain slow binocular rivalry rate in bipolar disorder: support for a perceptual endophenotype. Bipolar Disorders, . doi:10.1111/bdi.12515


Author Law, Phillip C. F.
Gurvich, Caroline T.
Ngo, Trung T.
Miller, Steven M.
Title Evidence that eye-movement profiles do not explain slow binocular rivalry rate in bipolar disorder: support for a perceptual endophenotype
Journal name Bipolar Disorders   Check publisher's open access policy
ISSN 1399-5618
1398-5647
Publication date 2017-07-17
Sub-type Article (original research)
DOI 10.1111/bdi.12515
Open Access Status Not yet assessed
Total pages 12
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Objectives: Presenting conflicting images simultaneously, one to each eye, produces perceptual alternations known as binocular rivalry (BR). Slow BR rate has been proposed as an endophenotype for bipolar disorder (BD) for use in large-scale genome-wide association studies. However, the trait could conceivably reflect eye movement (EM) dysfunction in BD rather than anomalous perceptual processing per se. To address this question, we examined the relationship between EM profiles and BR rate for various stimulus types in BD and healthy subjects. We also examined differences in EM profiles between these groups.

Methods: Employing a repeated-measures within-subjects design, 20 BD outpatients and 20 age- and sex-matched healthy controls completed EM tasks and separate BR tasks involving a range of stimuli with different drift speeds. The association between each EM measure and BR rate was examined with correlational analyses for all stimulus conditions in both groups. Between-group comparisons were performed to determine any differences in those EM measures. Corresponding Bayesian analyses were also conducted.

Results: There were no EM measures that showed a significant relationship with BR rate in either the BD group or the healthy group (P≥7.87×10−3), where those EM measures were also significantly different between the BD and healthy groups (P≥1.32 × 10−2). These findings were verified with Bayes factors.

Conclusions: The results provide evidence that EM profiles do not explain the slow BR endophenotype for BD, thus indicating that the trait reflects anomalous perceptual processing per se. This perceptual trait can be employed in clinical, genetic, mechanistic and pathophysiological studies.
Keyword Bayes factors
Binocular rivalry
Bipolar disorder
Endophenotype
Individual variation
Perceptual alternation rate
Saccadic eye movements
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Supporting Information: http://onlinelibrary.wiley.com/wol1/doi/10.1111/bdi.12515/suppinfo

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
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Created: Tue, 18 Jul 2017, 11:17:41 EST by Trung Thanh Ngo on behalf of Mater Research Institute-UQ