Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015

Roth, Gregory A., Johnson, Catherine, Abajobir, Amanuel, Abd-Allah, Foad, Abera, Semaw Ferede, Abyu, Gebre, Ahmed, Muktar, Aksut, Baran, Alam, Tahiya, Alam, Khurshid, Alla, Francois, Alvis-Guzman, Nelson, Amrock, Stephen, Ansari, Hossein, Arnlov, Johan, Asayesh, Hamid, Atey, Tesfay Mehari, Avila-Burgos, Leticia, Awasthi, Ashish, Banerjee, Amitava, Barac, Aleksandra, Barnighausen, Till, Barregard, Lars, Bedi, Neeraj, Ketema, Ezra Belay, Bennett, Derrick, Berhe, Gebremedhin, Bhutta, Zulfiqar, Bitew, Shimelash, Carapetis, Jonathan, Carrero, Juan Jesus, Malta, Deborah Carvalho, Andres Castaneda-Orjuela, Carlos, Castillo-Rivas, Jacqueline, Catala-Lopez, Ferran, Choi, Jee-Young, Christensen, Hanne, Cirillo, Massimo, Cooper, Leslie, Jr., Criqui, Michael, Cundiff, David, Damasceno, Albertino, Dandona, Lalit, Dandona, Rakhi, Davletov, Kairat, Dharmaratne, Samath, Dorairaj, Prabhakaran, Dubey, Manisha, Ehrenkranz, Rebecca, Zaki, Maysaa El Sayed, Faraon, Emerito Jose A., Esteghamati, Alireza, Farid, Talha, Farvid, Maryam, Feigin, Valery, Ding, Eric L., Fowkes, Gerry, Gebrehiwot, Tsegaye, Gillum, Richard, Gold, Audra, Gona, Philimon, Gupta, Rajeev, Habtewold, Tesfa Dejenie, Hafezi-Nejad, Nima, Hailu, Tesfaye, Hailu, Gessessew Bugssa, Hankey, Graeme, Hassen, Hamid Yimam, Abate, Kalkidan Hassen, Havmoeller, Rasmus, Hay, Simon I., Horino, Masako, Hotez, Peter J., Jacobsen, Kathryn, James, Spencer, Javanbakht, Mehdi, Jeemon, Panniyammakal, John, Denny, Jonas, Jost, Kalkonde, Yogeshwar, Karimkhani, Chante, Kasaeian, Amir, Khader, Yousef, Khan, Abdur, Khang, Young-Ho, Khera, Sahil, Khoja, Abdullah T., Khubchandani, Jagdish, Kim, Daniel, Kolte, Dhaval, Kosen, Soewarta, Krohn, Kristopher J., Kumar, G. Anil, Kwan, Gene F., Lal, Dharmesh Kumar, Larsson, Anders, Linn, Shai, Lopez, Alan, Lotufo, Paulo A., Abd El Razek, Hassan Magdy, Malekzadeh, Reza, Mazidi, Mohsen, Meier, Toni, Meles, Kidanu Gebremariam, Mensah, George, Meretoja, Atte, Mezgebe, Haftay, Miller, Ted, Mirrakhimov, Erkin, Mohammed, Shafiu, Moran, Andrew E., Musa, Kamarul Imran, Narula, Jagat, Neal, Bruce, Ngalesoni, Frida, Grant Nguyen, Obermeyer, Carla Makhlouf, Owolabi, Mayowa, Patton, George, Pedro, Joao, Qato, Dima, Qorbani, Mostafa, Rahimi, Kazem, Rai, Rajesh Kumar, Rawaf, Salman, Ribeiro, Antonio, Safiri, Saeid, Salomon, Joshua A., Santos, Itamar, Milicevic, Milena Santric, Sartorius, Benn, Schutte, Aletta, Sepanlou, Sadaf, Shaikh, Masood Ali, Shin, Min-Jeong, Shishehbor, Mehdi, Shore, Hirbo, Santos Silva, Diego Augusto, Sobngwi, Eugene, Stranges, Saverio, Swaminathan, Soumya, Tabares-Seisdedos, Rafael, Atnafu, Niguse Tadele, Tesfay, Fisaha, Thakur, J. S., Thrift, Amanda, Topor-Madry, Roman, Truelsen, Thomas, Tyrovolas, Stefanos, Ukwaja, Kingsley Nnanna, Uthman, Olalekan, Vasankari, Tommi, Vlassov, Vasiliy, Vollset, Stein Emil, Wakayo, Tolassa, Watkins, David, Weintraub, Robert, Werdecker, Andrea, Westerman, Ronny, Wiysonge, Charles Shey, Wolfe, Charles, Workicho, Abdulhalik, Xu, Gelin, Yano, Yuichiro, Yip, Paul, Yonemoto, Naohiro, Younis, Mustafa, Yu, Chuanhua, Vos, Theo, Naghavi, Mohsen and Murray, Christopher (2017) Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. Journal of the American College of Cardiology, 70 1: 1-25. doi:10.1016/j.jacc.2017.04.052


Author Roth, Gregory A.
Johnson, Catherine
Abajobir, Amanuel
Abd-Allah, Foad
Abera, Semaw Ferede
Abyu, Gebre
Ahmed, Muktar
Aksut, Baran
Alam, Tahiya
Alam, Khurshid
Alla, Francois
Alvis-Guzman, Nelson
Amrock, Stephen
Ansari, Hossein
Arnlov, Johan
Asayesh, Hamid
Atey, Tesfay Mehari
Avila-Burgos, Leticia
Awasthi, Ashish
Banerjee, Amitava
Barac, Aleksandra
Barnighausen, Till
Barregard, Lars
Bedi, Neeraj
Ketema, Ezra Belay
Bennett, Derrick
Berhe, Gebremedhin
Bhutta, Zulfiqar
Bitew, Shimelash
Carapetis, Jonathan
Carrero, Juan Jesus
Malta, Deborah Carvalho
Andres Castaneda-Orjuela, Carlos
Castillo-Rivas, Jacqueline
Catala-Lopez, Ferran
Choi, Jee-Young
Christensen, Hanne
Cirillo, Massimo
Cooper, Leslie, Jr.
Criqui, Michael
Cundiff, David
Damasceno, Albertino
Dandona, Lalit
Dandona, Rakhi
Davletov, Kairat
Dharmaratne, Samath
Dorairaj, Prabhakaran
Dubey, Manisha
Ehrenkranz, Rebecca
Zaki, Maysaa El Sayed
Faraon, Emerito Jose A.
Esteghamati, Alireza
Farid, Talha
Farvid, Maryam
Feigin, Valery
Ding, Eric L.
Fowkes, Gerry
Gebrehiwot, Tsegaye
Gillum, Richard
Gold, Audra
Gona, Philimon
Gupta, Rajeev
Habtewold, Tesfa Dejenie
Hafezi-Nejad, Nima
Hailu, Tesfaye
Hailu, Gessessew Bugssa
Hankey, Graeme
Hassen, Hamid Yimam
Abate, Kalkidan Hassen
Havmoeller, Rasmus
Hay, Simon I.
Horino, Masako
Hotez, Peter J.
Jacobsen, Kathryn
James, Spencer
Javanbakht, Mehdi
Jeemon, Panniyammakal
John, Denny
Jonas, Jost
Kalkonde, Yogeshwar
Karimkhani, Chante
Kasaeian, Amir
Khader, Yousef
Khan, Abdur
Khang, Young-Ho
Khera, Sahil
Khoja, Abdullah T.
Khubchandani, Jagdish
Kim, Daniel
Kolte, Dhaval
Kosen, Soewarta
Krohn, Kristopher J.
Kumar, G. Anil
Kwan, Gene F.
Lal, Dharmesh Kumar
Larsson, Anders
Linn, Shai
Lopez, Alan
Lotufo, Paulo A.
Abd El Razek, Hassan Magdy
Malekzadeh, Reza
Mazidi, Mohsen
Meier, Toni
Meles, Kidanu Gebremariam
Mensah, George
Meretoja, Atte
Mezgebe, Haftay
Miller, Ted
Mirrakhimov, Erkin
Mohammed, Shafiu
Moran, Andrew E.
Musa, Kamarul Imran
Narula, Jagat
Neal, Bruce
Ngalesoni, Frida
Grant Nguyen
Obermeyer, Carla Makhlouf
Owolabi, Mayowa
Patton, George
Pedro, Joao
Qato, Dima
Qorbani, Mostafa
Rahimi, Kazem
Rai, Rajesh Kumar
Rawaf, Salman
Ribeiro, Antonio
Safiri, Saeid
Salomon, Joshua A.
Santos, Itamar
Milicevic, Milena Santric
Sartorius, Benn
Schutte, Aletta
Sepanlou, Sadaf
Shaikh, Masood Ali
Shin, Min-Jeong
Shishehbor, Mehdi
Shore, Hirbo
Santos Silva, Diego Augusto
Sobngwi, Eugene
Stranges, Saverio
Swaminathan, Soumya
Tabares-Seisdedos, Rafael
Atnafu, Niguse Tadele
Tesfay, Fisaha
Thakur, J. S.
Thrift, Amanda
Topor-Madry, Roman
Truelsen, Thomas
Tyrovolas, Stefanos
Ukwaja, Kingsley Nnanna
Uthman, Olalekan
Vasankari, Tommi
Vlassov, Vasiliy
Vollset, Stein Emil
Wakayo, Tolassa
Watkins, David
Weintraub, Robert
Werdecker, Andrea
Westerman, Ronny
Wiysonge, Charles Shey
Wolfe, Charles
Workicho, Abdulhalik
Xu, Gelin
Yano, Yuichiro
Yip, Paul
Yonemoto, Naohiro
Younis, Mustafa
Yu, Chuanhua
Vos, Theo
Naghavi, Mohsen
Murray, Christopher
Title Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015
Journal name Journal of the American College of Cardiology   Check publisher's open access policy
ISSN 1558-3597
0735-1097
Publication date 2017-07-04
Sub-type Article (original research)
DOI 10.1016/j.jacc.2017.04.052
Open Access Status Not yet assessed
Volume 70
Issue 1
Start page 1
End page 25
Total pages 25
Place of publication San Diego, CA, United States
Publisher Elsevier
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
Abstract Background: The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world. Objectives: The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden. Methods: CVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries. Years lived with disability (YLD) were estimated by multiplying prevalence by disability weights. Years of life lost (YLL) were estimated by multiplying age-specific CVD deaths by a reference life expectancy. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility. Results: In 2015, there were an estimated 422.7 million cases of CVD (95% uncertainty interval: 415.53 to 427.87 million cases) and 17.92 million CVD deaths (95% uncertainty interval: 17.59 to 18.28 million CVD deaths). Declines in the age-standardized CVD death rate occurred between 1990 and 2015 in all high-income and some middle-income countries. Ischemic heart disease was the leading cause of CVD health lost globally, as well as in each world region, followed by stroke. As SDI increased beyond 0.25, the highest CVD mortality shifted from women to men. CVD mortality decreased sharply for both sexes in countries with an SDI >0.75. Conclusions: CVDs remain a major cause of health loss for all regions of the world. Sociodemographic change over the past 25 years has been associated with dramatic declines in CVD in regions with very high SDI, but only a gradual decrease or no change in most regions. Future updates of the GBD study can be used to guide policymakers who are focused on reducing the overall burden of noncommunicable disease and achieving specific global health targets for CVD.
Formatted abstract
Background

The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world.

Objectives

The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden.

Methods

CVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries. Years lived with disability (YLD) were estimated by multiplying prevalence by disability weights. Years of life lost (YLL) were estimated by multiplying age-specific CVD deaths by a reference life expectancy. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility.

Results


In 2015, there were an estimated 422.7 million cases of CVD (95% uncertainty interval: 415.53 to 427.87 million cases) and 17.92 million CVD deaths (95% uncertainty interval: 17.59 to 18.28 million CVD deaths). Declines in the age-standardized CVD death rate occurred between 1990 and 2015 in all high-income and some middle-income countries. Ischemic heart disease was the leading cause of CVD health lost globally, as well as in each world region, followed by stroke. As SDI increased beyond 0.25, the highest CVD mortality shifted from women to men. CVD mortality decreased sharply for both sexes in countries with an SDI >0.75.

Conclusions

CVDs remain a major cause of health loss for all regions of the world. Sociodemographic change over the past 25 years has been associated with dramatic declines in CVD in regions with very high SDI, but only a gradual decrease or no change in most regions. Future updates of the GBD study can be used to guide policymakers who are focused on reducing the overall burden of noncommunicable disease and achieving specific global health targets for CVD.
Keyword Cause of death
Epidemiology
Global health
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID IA/CPHI/14/1/501497
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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