Clinical features of human infection with scedosporium inflatum

G.M.Wood G.M.WoodGillian M.G.M.Wood G.WoodGillian M. (1992) Clinical features of human infection with scedosporium inflatum. Clinical Infectious Diseases, 14 5: 1027-1033. doi:10.1093/clinids/14-5-1027

Author G.M.Wood G.M.WoodGillian M.G.M.Wood G.WoodGillian M.
Title Clinical features of human infection with scedosporium inflatum
Journal name Clinical Infectious Diseases   Check publisher's open access policy
ISSN 1537-6591
Publication date 1992-05-01
Sub-type Article (original research)
DOI 10.1093/clinids/14-5-1027
Open Access Status Not yet assessed
Volume 14
Issue 5
Start page 1027
End page 1033
Total pages 7
Language eng
Subject 2726 Microbiology (medical)
2725 Infectious Diseases
Abstract We report on 17 Australian cases of human infection or colonization with Scedosporium inflatum. The spectrum of clinical manifestations was similar to that in infection caused by Scedosporium apiospermum. The patients were classified into three groups. Four immunocompetent patients who presented with localized infections of a joint, nail bed, eye, or sphenoidal sinus made up the first group. Our first case, in a boy with posttraumatic septic arthritis, responded to surgical drainage with amphotericin B followed by treatment with itraconazole. The other three cases were cured by surgery alone. The second group consisted of five immunocompromised patients who presented with disseminated infections in a variety of sites. Four of these patients did not respond to antifungal therapy and died. The fifth apparently responded to antifungal drugs after correction of his neutropenia. The third group included eight patients with asymptomatic colonization in the external ear (five cases) or respiratory secretions (three cases). The nine isolates of S. inflatum tested by both disk and agar dilution methods were resistant to antifungal drugs. In our first case, which responded clinically to itraconazole, the MIC of this drug for the fungal isolate was 25 μg/mL. Thus S. inflatum can cause a broad spectrum of human infections whose severity and prognosis depend largely on the host’s immune status.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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