Audit of selective and non-selective non-steroidal anti-inflammatory drug use in rural general practice

Cutts, C., La Caze, A. and Tett, S.E. (2003) Audit of selective and non-selective non-steroidal anti-inflammatory drug use in rural general practice. Journal of Pharmacy Practice and Research, 33 1: 70-73.


Author Cutts, C.
La Caze, A.
Tett, S.E.
Title Audit of selective and non-selective non-steroidal anti-inflammatory drug use in rural general practice
Journal name Journal of Pharmacy Practice and Research   Check publisher's open access policy
ISSN 1445-937X
Publication date 2003-01-01
Sub-type Article (original research)
Volume 33
Issue 1
Start page 70
End page 73
Total pages 4
Editor J. Low
Place of publication Australia
Publisher SHPA
Language eng
Subject C1
321208 Primary Health Care
730209 Rural health
Abstract Aim: To identify the demographics and risk factors in a selected patient population prescribed non-selective and cyclo-oxygenase-2 (COX- 2) selective non-steroidal anti-inflammatory drugs (NSAIDs). Method: A structured clinical self-audit form was distributed in January to March 2001 to 155 interested general practitioners (GPs) in rural Queensland. Results: Seventy one GPs participated in the audit and contributed 1417 patient records - 790 patients had received nonselective NSAIDs and 627 had received COX-2 inhibitors (celecoxib or rofecoxib). Patients who received COX-2 inhibitors were significantly older, more likely to have clinically important concomitant illness, and more likely to be taking medication known to interact with NSAIDs. They were also twice as likely to have two or more risk factors for adverse effects. The most common reasons for switching from an NSAID to a COX-2 inhibitor were reported to be a previous side effect from an NSAID (primarily related to gastrointestinal effects) or the doctor's perception of the superior efficacy of COX-2 inhibitor therapy. Conclusions: This study has shown that COX-2 inhibitors were used in a distinctly different patient population compared to non-selective NSAIDs. There were significant variations in the demographics and number of risk factors - for example, cardiovascular and renal - between the two identified populations. These differences may be due to doctors selecting COX-2 inhibitors for patients at high risk of gastrointestinal complications. However, the prescribing pattern may also be partly due to misconceptions about the relative safety and efficacy of COX-2 inhibitor drugs.
Keyword Australia
General Practice
Rural
NSAIDs
COX- 2
Queensland
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Pharmacy Publications
 
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Created: Wed, 15 Aug 2007, 12:08:20 EST