Changes in host immune-endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomes

Kleynhans, Leanie, Ruzive, Sheena, Ehlers, Lizaan, Thiart, Lani, Chegou, Novel N., Conradie, Magda, Kriel, Magdalena, Stanley, Kim, van der Spuy, Gian D., Kidd, Martin, van Helden, Paul D., Walzl, Gerhard and Ronacher, Katharina (2017) Changes in host immune-endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomes. Frontiers in Immunology, 8 JUN: 690. doi:10.3389/fimmu.2017.00690


Author Kleynhans, Leanie
Ruzive, Sheena
Ehlers, Lizaan
Thiart, Lani
Chegou, Novel N.
Conradie, Magda
Kriel, Magdalena
Stanley, Kim
van der Spuy, Gian D.
Kidd, Martin
van Helden, Paul D.
Walzl, Gerhard
Ronacher, Katharina
Title Changes in host immune-endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomes
Journal name Frontiers in Immunology   Check publisher's open access policy
ISSN 1664-3224
Publication date 2017-06-15
Year available 2017
Sub-type Article (original research)
DOI 10.3389/fimmu.2017.00690
Open Access Status DOI
Volume 8
Issue JUN
Start page 690
Total pages 13
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Subject 2723 Immunology and Allergy
2403 Immunology
Abstract A bidirectional communication between the immune and endocrine systems exists and facilitates optimum responses in the host during infections. This is in part achieved through changes in secretion patterns of hypothalamic hormones induced by inflammatory cytokines. The aim of this study was to elucidate the immune–endocrine alterations during tuberculosis (TB) treatment in patients with cured and failed TB treatment outcomes. Blood samples were collected from 27 cured and 10 failed patients and hormone as well as cytokine concentrations quantified at baseline, week 4, and month 6 of TB treatment. Hormone profiles of the two treatment outcome groups were different from each other prior to as well as during TB treatment. Treatment response effects were observed for cortisol, estradiol, T3, T4 ghrelin, leptin, amylin, adiponectin, and dehydroepiandrosterone (DHEA). Trends suggest that T4, amylin, and DHEA concentrations were different between treatment outcomes, although these did not reach statistical significance. Relationships between endocrine and inflammatory markers and the biological pathways involved differed between cured and failed treatment patients. These results highlight the complex interaction between the endocrine and immune system during active TB disease and throughout treatment and suggest that endocrine markers in conjunction with inflammatory markers may be useful in predicting unfavorable treatment outcomes.
Keyword Tuberculosis
Biomarkers
Immune
Endocrine
Cytokines
Metabolic hormones
Steroid hormones
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID U01 AI115619
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
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Created: Thu, 06 Jul 2017, 08:23:12 EST by Katharina Ronacher on behalf of Mater Research Institute-UQ