Systemic apomorphine alters HPA axis responses to interleukin-1 beta adminstration but not sound stress

Buller, K. M., Crane, J. W., Spencer, S. J. and Day, T. A. (2003) Systemic apomorphine alters HPA axis responses to interleukin-1 beta adminstration but not sound stress. Psychoneuroendocrinology, 28 6: 715-732. doi:10.1016/S0306-4530(02)00065-3

Author Buller, K. M.
Crane, J. W.
Spencer, S. J.
Day, T. A.
Title Systemic apomorphine alters HPA axis responses to interleukin-1 beta adminstration but not sound stress
Formatted title
Systemic apomorphine alters HPA axis responses to interleukin-1β adminstration but not sound stress
Journal name Psychoneuroendocrinology   Check publisher's open access policy
ISSN 0306-4530
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1016/S0306-4530(02)00065-3
Open Access Status
Volume 28
Issue 6
Start page 715
End page 732
Total pages 18
Editor R. Dantzer
Place of publication England
Publisher Pergamon-Elsevier
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract Apomorphine is a dopamine receptor agonist that was recently licensed for the treatment of erectile dysfunction. However, although sexual activity can be stressful, there has been little investigation into whether treatments for erectile dysfunction affect stress responses. We have examined whether a single dose of apomorphine, sufficient to produce penile erections (50 mug/kg, i.a.), can alter basal or stress-induced plasma ACTH levels, or activity of central pathways thought to control the hypothalamic-pituitary-adrenal axis in rats. An immune challenge (interleukin-1beta, 1 mug/kg, i.a.) was used as a physical stressor while sound stress (100 dB white noise, 30 min) was used as a psychological stressor. Intravascular administration of apomorphine had no effect on basal ACTH levels but did substantially increase the number of Fos-positive amygdala and nucleus tractus solitarius catecholamine cells. Administration of apomorphine prior to immune challenge augmented the normal ACTH response to this stressor at 90 min and there was a corresponding increase in the number of Fos-positive paraventricular nucleus corticotropin-releasing factor cells, paraventricular nucleus oxytocin cells and nucleus tractus solitarius catecholamine cells. However, apomorphine treatment did not alter ACTH or Fos responses to sound stress. These data suggest that erection-inducing levels of apomorphine interfere with hypothalamic-pituitary-adrenal axis inhibitory feedback mechanisms in response to a physical stressor, but have no effect on the response to a psychological stressor. Consequently, it is likely that apomorphine acts on a hypothalamic-pituitary-adrenal axis control pathway that is unique to physical stressors. A candidate for this site of action is the nucleus tractus solitarius catecholamine cell population and, in particular, A2 noradrenergic neurons. (C) 2003 Elsevier Science Ltd. All rights reserved.
Keyword Endocrinology & Metabolism
A2 Noradrenergic Cells
Hypothalamic-pituitary-adrenal Axis
Interleukin-1 Beta
Sound Stress
Hypothalamic Paraventricular Nucleus
Penile Erection
Dopamine-d3 Receptor
Central Amygdala
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 12:03:47 EST