Challenging the dogma: the hidden layer of non-protein-coding RNAs in complex organisms

Mattick, John S. (2003) Challenging the dogma: the hidden layer of non-protein-coding RNAs in complex organisms. Bioessays, 25 10: 930-939. doi:10.1002/bies.10332


Author Mattick, John S.
Title Challenging the dogma: the hidden layer of non-protein-coding RNAs in complex organisms
Journal name Bioessays   Check publisher's open access policy
ISSN 0265-9247
Publication date 2003-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/bies.10332
Open Access Status Not Open Access
Volume 25
Issue 10
Start page 930
End page 939
Total pages 10
Editor Wilkins
Adam, S.
Place of publication Cambridge, UK
Publisher John Wiley & Sons Ltd.
Language eng
Subject C1
270208 Molecular Evolution
780105 Biological sciences
Abstract The central dogma of biology holds that genetic information normally flows from DNA to RNA to protein. As a consequence it has been generally assumed that genes generally code for proteins, and that proteins fulfil not only most structural and catalytic but also most regulatory functions, in all cells, from microbes to mammals. However, the latter may not be the case in complex organisms. A number of startling observations about the extent of non-protein-coding RNA (ncRNA) transcription in the higher eukaryotes and the range of genetic and epigenetic phenomena that are RNA-directed suggests that the traditional view of the structure of genetic regulatory systems in animals and plants may be incorrect. ncRNA dominates the genomic output of the higher organisms and has been shown to control chromosome architecture, mRNA turnover and the developmental timing of protein expression, and may also regulate transcription and alternative splicing. This paper re-examines the available evidence and suggests a new framework for considering and understanding the genomic programming of biological complexity, autopoletic development and phenotypic variation. BioEssays 25:930-939,2003. (C) 2003 Wiley Periodicals, Inc.
Keyword Biochemistry & Molecular Biology
Biology
Noncoding Rna
Messenger-rna
Human Genome
Histone H3
Bithorax Complex
Antisense Rna
Human-disease
Rat-brain
Gene
Identification
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 326 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 361 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 11:56:12 EST