Acquisition and invasiveness of different serotypes of Streptococcus pneumoniae in young children

Smith T., Lehmann D., Montgomery J., Gratten M., Riley I.D. and Alpers M.P. (1993) Acquisition and invasiveness of different serotypes of Streptococcus pneumoniae in young children. Epidemiology and Infection, 111 1: 27-39. doi:10.1017/S0950268800056648


Author Smith T.
Lehmann D.
Montgomery J.
Gratten M.
Riley I.D.
Alpers M.P.
Title Acquisition and invasiveness of different serotypes of Streptococcus pneumoniae in young children
Journal name Epidemiology and Infection   Check publisher's open access policy
ISSN 1469-4409
Publication date 1993-01-01
Sub-type Article (original research)
DOI 10.1017/S0950268800056648
Open Access Status Not yet assessed
Volume 111
Issue 1
Start page 27
End page 39
Total pages 13
Language eng
Subject 2713 Epidemiology
2725 Infectious Diseases
Abstract Rates of acquisition and mean duration of nasal carriage of different serotypes of Streptococcus pneumoniae have been estimated by fitting a stochastic model to longitudinal carriage data in children from Papua New Guinea. Immunogenicity and two indices of relative invasiveness were determined for each serotype. Immunogenic serotypes were less frequently acquired and were carried for shorter periods, but no relationship between immunogenicity and invasiveness was apparent using either index of invasiveness. Frequent invasion was associated with a high acquisition rate and high frequency and prolonged duration of carriage. Carriage studies can provide a broad indication of which serotypes cause invasive disease but not the proportion of disease due to individual serotypes; some serotypes which cause invasive disease (e.g. serotype 46) are not found even in extensive carriage studies. The antibiotic resistance of carriage organisms, however, does approximate the resistance patterns of invasive organisms and thus may be used to monitor changing patterns of antimicrobial susceptibility in the community.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 92 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 04 Jul 2017, 00:05:13 EST by System User