Parvalbumin-, calbindin-, and calretinin-immunoreactive neurons in the prefrontal cortex of the owl monkey (Aotus trivirgatus): A standardized quantitative comparison with sensory and motor areas

Elston, GN and Gonzalez-Albo, MC (2003) Parvalbumin-, calbindin-, and calretinin-immunoreactive neurons in the prefrontal cortex of the owl monkey (Aotus trivirgatus): A standardized quantitative comparison with sensory and motor areas. Brain Behavior And Evolution, 62 1: 19-30. doi:10.1159/000071957


Author Elston, GN
Gonzalez-Albo, MC
Title Parvalbumin-, calbindin-, and calretinin-immunoreactive neurons in the prefrontal cortex of the owl monkey (Aotus trivirgatus): A standardized quantitative comparison with sensory and motor areas
Journal name Brain Behavior And Evolution   Check publisher's open access policy
ISSN 0006-8977
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1159/000071957
Open Access Status Not yet assessed
Volume 62
Issue 1
Start page 19
End page 30
Total pages 12
Editor W. Wilczynski
Place of publication Switzerland
Publisher Karger Medical and Scientific Publishers
Language eng
Subject C1
270502 Neurobiology
780106 Political science and public policy
Abstract Recent studies have revealed regional variation in the density and distribution of inhibitory neurons in different cortical areas, which are thought to reflect area-specific specializations in cortical circuitry. However, there are as yet few standardized quantitative data regarding how the inhibitory circuitry in prefrontal cortex (PFC), which is thought to be involved in executive functions such as cognition, emotion and decision making, compares to that in other cortical areas. Here we used immunohistochemical techniques to determine the density and distribution of parvalbumin (PV)-, calbindin (CB)-, and calretinin (CR)-immunoreactive (ir) neurons and axon terminals in the dorsolateral and orbital PFC of the owl monkey (Aotus trivirgatus), and compared them directly with data obtained using the same techniques in 11 different visual, somatosensory and motor areas. We found marked differences in the density of PV-ir, CB-ir, and CR-ir interneurons in several cortical areas. One hundred and twenty eight of all 234 possible between-area pairwise comparisons were significantly different. The density of specific subpopulations of these cells also varied among cortical areas, as did the density of axon terminals. Comparison of PFC with other cortical areas revealed that 40 of all 66 possible statistical comparisons of the density of PV-ir, CB-ir, and CR-ir cells were significantly different. We also found evidence for heterogeneity in the pattern of labeling of PV-ir, CB-ir, and CR-ir cells and axon terminals between the dorsolateral and orbital subdivisions of PFC. These data are likely to reflect basic differences in interneuron circuitry, which are likely to influence inhibitory function in the cortex. Copyright (C) 2003 S. Karger AG, Basel.
Keyword Behavioral Sciences
Neurosciences
Mammals
Primate
Cortex
Interneurons
Gaba
Calcium-binding Proteins
Human Temporal Cortex
Strepsirhine Primate Galago
Granular Frontal-cortex
Human Cerebral-cortex
Large Basket Cells
Visual-cortex
Synaptic Connections
Pyramidal Neurons
Macaque Monkey
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2004 Higher Education Research Data Collection
Queensland Brain Institute Publications
 
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Created: Wed, 15 Aug 2007, 11:47:44 EST