Genetic disruption of the growth hormone receptor does not influence motoneuron survival in the developing mouse

Parsons, Sean A., Banks, Glen B., Rowland, Jenny A., Coschigano, Karen T., Kopchick, John J., Waters, Michael J. and Noakes, Peter G. (2003) Genetic disruption of the growth hormone receptor does not influence motoneuron survival in the developing mouse. International Journal of Developmental Biology, 47 1: 41-49.


Author Parsons, Sean A.
Banks, Glen B.
Rowland, Jenny A.
Coschigano, Karen T.
Kopchick, John J.
Waters, Michael J.
Noakes, Peter G.
Title Genetic disruption of the growth hormone receptor does not influence motoneuron survival in the developing mouse
Journal name International Journal of Developmental Biology   Check publisher's open access policy
ISSN 0214-6282
Publication date 2003-02-01
Year available 2003
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 47
Issue 1
Start page 41
End page 49
Total pages 9
Editor J. Archaga
Place of publication Bilbao, Spain
Publisher University of the Basque Country Press
Language eng
Subject C1
320602 Cell Physiology
730105 Endocrine organs and diseases (incl. diabetes)
Abstract In the rodent central nervous system (CNS) during the five days prior to birth, both growth hormone (GH) and its receptor (GHR) undergo transient increases in expression to levels considerably higher than those found postnatally. This increase in expression coincides with the period of neuronal programmed cell death (PCD) in the developing CNS. To evaluate the involvement of growth hormone in the process of PCD, we have quantified the number of motoneurons in the spinal cord and brain stem of wild type and littermate GHR-deficient mice at the beginning and end of the neuronal PCD period. We found no change in motoneuron survival in either the brachial or lumbar lateral motor columns of the spinal cord or in the trochlear, trigeminal, facial or hypoglossal nuclei in the brain stem. We also found no significant differences in spinal cord volume, muscle fiber diameter, or body weight of GHR-deficient fetal mice when compared to their littermate controls. Therefore, despite considerable in vitro evidence for GH action on neurons and glia, genetic disruption of GHR signalling has no effect on prenatal motoneuron number in the mouse, under normal physiological conditions. This may be a result of compensation by the signalling of other neurotrophic cytokines.
Keyword Developmental Biology
Growth Hormone Receptor
Motoneuron
Apoptosis
Nervous System
Central-nervous-system
Programmed Cell-death
Rat Spinal-cord
Chick-embryo
Factor-i
Phosphatidylinositol 3-kinase
Laron-syndrome
Knockout Mice
Neuron Death
Expression
Q-Index Code C1
Institutional Status UQ

 
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Created: Wed, 15 Aug 2007, 11:30:06 EST