Expression of ephs and ephrins in developing mouse inner ear

Pickles, James O. (2003) Expression of ephs and ephrins in developing mouse inner ear. Hearing Research, 178 1-2: 44-51. doi:10.1016/S0378-5955(03)00029-7

Author Pickles, James O.
Title Expression of ephs and ephrins in developing mouse inner ear
Journal name Hearing Research   Check publisher's open access policy
ISSN 0378-5955
Publication date 2003-04-01
Sub-type Article (original research)
DOI 10.1016/S0378-5955(03)00029-7
Open Access Status Not yet assessed
Volume 178
Issue 1-2
Start page 44
End page 51
Total pages 8
Editor A. Moller
Place of publication The Netherlands
Publisher Elsevier
Language eng
Subject C1
270602 Animal Physiology - Cell
730111 Hearing, vision, speech and their disorders
1116 Medical Physiology
Abstract Levels of expression of mRNAs encoding the different Ephs and ephrins were measured by semi-quantitative reverse-transcription polymerase chain reaction in developing mouse whole inner ears, and in dissected fractions of the neonatal mouse inner ear. Nineteen of the 24 known Ephs and ephrins were surveyed. The results showed that between embryonic age (E) 11.5 days and E12.5, levels increased 10-300 times per unit of tissue. In neonatal mice, the fraction containing combined organ of Corti and spiral ganglion showed relatively strong expression of EphA4, EphB3, ephrin-A3, ephrin-B2 and ephrin-B3. In the lateral wall, EphA4, ephrin-A3 and ephrin-B2 were strongly expressed, while ephrin-A3 was particularly strongly expressed in utricular and saccular sensory epithelia. The results suggest that the Ephs and ephrins are likely to play a part in the differentiation of the structures of the inner ear, and show which Ephs and ephrins are most likely to play important roles in the different structures. (C) 2003 Elsevier Science B.V. All rights reserved.
Keyword Neurosciences
Inner Ear
Vestibular System
Receptor Tyrosine Kinases
Neural Crest Migration
Q-Index Code C1
Institutional Status UQ

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Created: Wed, 15 Aug 2007, 11:29:43 EST