CD40 and dendritic cell function

O'Sullivan, Brendan and Thomas, Ranjeny (2003) CD40 and dendritic cell function. Critical Reviews In Immunology, 23 1-2: 83-107. doi:10.1615/CritRevImmunol.v23.i12.50

Author O'Sullivan, Brendan
Thomas, Ranjeny
Title CD40 and dendritic cell function
Journal name Critical Reviews In Immunology   Check publisher's open access policy
ISSN 1040-8401
Publication date 2003-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1615/CritRevImmunol.v23.i12.50
Volume 23
Issue 1-2
Start page 83
End page 107
Total pages 25
Editor M. Z. Atassi
Place of publication New York
Publisher Begell House, Inc. Publishers
Language eng
Subject C1
730102 Immune system and allergy
320202 Cellular Immunology
110322 Rheumatology and Arthritis
1107 Immunology
Abstract CD40 has emerged as a key signaling pathway for the function of B cells, monocytes, and dendritic cells (DC) in the immune system, and plays a major role in inflammatory pathways of nonhemopoletic cells. CD40 is expressed by monocytes and DC and is up-regulated when DC migrate from the periphery to draining lymph nodes (DLN) in response to microbial challenge. CD154 signaling by MHC-restricted, activated CD4* T cells induces differentiation of DC, as defined by an increased surface expression of MHC, costimulatory, and adhesion molecules. Thus, CD40 functions in the adaptive immune response as a trigger for the expression of costimulatory molecules for efficient T-cell activation. CD40 ligation of DC also has the capacity to induce high levels of the cytokine IL-12, which polarizes CD4(+) T cells toward a T helper 1 (Th1) type, enhances proliferation of CD8(+) T cells, and activates NK cells. CD40 may also play an important role in the decision between tolerance and immunity and the generation of regulatory CD4(+) T cells that are thought to maintain peripheral self-tolerance in vivo.
Keyword Immunology
Dendritic Cells
Nf-kappa B
Cd8(+) T-cells
Hyper-igm Syndrome
Listeria-monocytogenes Infection
Exogenous Antigen Presentation
Cd40-cd40 Ligand Interaction
Cardiac Allograft Survival
X-linked Immunodeficiency
Activated Protein-kinase
Level Il-12 Production
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 95 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 100 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 11:25:28 EST