A model to investigate hepatic extraction of oxygen during anaesthesia in the dog

Mills, PC (2003) A model to investigate hepatic extraction of oxygen during anaesthesia in the dog. Research In Veterinary Science, 75 3: 179-183. doi:10.1016/S0034-5288(03)00140-1


Author Mills, PC
Title A model to investigate hepatic extraction of oxygen during anaesthesia in the dog
Journal name Research In Veterinary Science   Check publisher's open access policy
ISSN 0034-5288
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1016/S0034-5288(03)00140-1
Open Access Status Not Open Access
Volume 75
Issue 3
Start page 179
End page 183
Total pages 5
Editor G.A. Hall
Place of publication United Kingdom
Publisher Elsevier
Language eng
Subject C1
300502 Anaesthesiology and Intensive Care
780105 Biological sciences
Abstract Measurement of hepatic oxygen extraction was performed on six healthy Greyhound dogs over a two hour period. The Greyhounds were anaesthetised and a right subcostal surgical incision performed. Ultrasonic flow transducers were used to measure flow rate in the hepatic artery and the portal vein. The blood oxygen tensions in arterial blood and in the portal and hepatic veins were also measured. Hepatic oxygen extraction remained stable throughout the study, despite a steady decline in arterial blood pressure. The methodology described in this study provides a direct measure of oxygen uptake by the liver in the dog and could readily be used to investigate hepatic uptake of drugs. (C) 2003 Elsevier Ltd. All rights reserved.
Keyword Extraction
Oxygen
Anaesthesia
Dog
Veterinary Sciences
Hepatic
Oxygen Extraction
Liver Blood-flow
Venous Vascular Beds
Halothane
Greyhound
Consumption
Arterial
Disposition
Propranolol
Elimination
Responses
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 11:24:52 EST