Dynamics of Gray Matter Loss in Alzheimer's Disease

Thompson, P., Hayashi, K., de Zubicaray, G. I, Janke, A. L., Rose, S. E., Semple, J., Herman, D., Hong, M.S., Dittmer, S. S., Doddrell, D. M. and Toga, A. S. (2003) Dynamics of Gray Matter Loss in Alzheimer's Disease. The Journal of Neuroscience, 23 3: 994-1005.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ65295_OA.pdf Full text (open access) application/pdf 1.31MB 0
Author Thompson, P.
Hayashi, K.
de Zubicaray, G. I
Janke, A. L.
Rose, S. E.
Semple, J.
Herman, D.
Hong, M.S.
Dittmer, S. S.
Doddrell, D. M.
Toga, A. S.
Title Dynamics of Gray Matter Loss in Alzheimer's Disease
Journal name The Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2003-01-01
Year available 2003
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 23
Issue 3
Start page 994
End page 1005
Total pages 12
Place of publication USA
Publisher Society for Neuroscience
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract We detected and mapped a dynamically spreading wave of gray matter loss in the brains of patients with Alzheimer's disease (AD). The loss pattern was visualized in four dimensions as it spread over time from temporal and limbic cortices into frontal and occipital brain regions, sparing sensorimotor cortices. The shifting deficits were asymmetric (left hemisphere >right hemisphere) and correlated with progressively declining cognitive status ( p <0.0006). Novel brain mapping methods allowed us to visualize dynamic patterns of atrophy in 52 high-resolution magnetic resonance image scans of 12 patients with AD (age 68.4 +/- 1.9 years) and 14 elderly matched controls (age 71.4 +/- 0.9 years) scanned longitudinally (two scans; interscan interval 2.1 +/- 0.4 years). A cortical pattern matching technique encoded changes in brain shape and tissue distribution across subjects and time. Cortical atrophy occurred in a well defined sequence as the disease progressed, mirroring the sequence of neurofibrillary tangle accumulation observed in cross sections at autopsy. Advancing deficits were visualized as dynamic maps that change over time. Frontal regions, spared early in the disease, showed pervasive deficits later (>15% loss). The maps distinguished different phases of AD and differentiated AD from normal aging. Local gray matter loss rates (5.3 +/- 2.3% per year in AD v 0.9 +/- 0.9% per year in controls) were faster in the left hemisphere ( p < 0.029) than the right. Transient barriers to disease progression appeared at limbic/frontal boundaries. This degenerative sequence, observed in vivo as it developed, provides the first quantitative, dynamic visualization of cortical atrophic rates in normal elderly populations and in those with dementia.
Keyword Aging
Magnetic Resonance Imaging
Brain Mapping
Voxel-based Morphometry
Temporal-lobe Atrophy
Cognitive Decline
Cerebral Atrophy
Neurofibrillary Tangles
Dendritic Extent
Brain Maturation
Senile Dementia
Neuronal Loss
Q-Index Code C1
Grant ID M01 RR00865
P01 MH52176
R01 LM05639
Institutional Status UQ

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 637 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 697 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 11:22:55 EST