Genetic and Environmental Influences on Migraine: A Twin Study Across Six Countries

Mulder, Elles J., van Baal, Caroline, Gaistz, David, Kallela, Mikko, Kaprio, Jaakko, Svensson, Dan A., Nyholt, Dale R., Martin, Nicholas G., MacGregor, Alex J., Cherkas, Lynn F., Boomsma, Dorret I. and Palotie, Aarno (2003) Genetic and Environmental Influences on Migraine: A Twin Study Across Six Countries. Twin Research, 6 5: 422-431. doi:10.1375/136905203770326420

Author Mulder, Elles J.
van Baal, Caroline
Gaistz, David
Kallela, Mikko
Kaprio, Jaakko
Svensson, Dan A.
Nyholt, Dale R.
Martin, Nicholas G.
MacGregor, Alex J.
Cherkas, Lynn F.
Boomsma, Dorret I.
Palotie, Aarno
Title Genetic and Environmental Influences on Migraine: A Twin Study Across Six Countries
Journal name Twin Research   Check publisher's open access policy
ISSN 1369-0523
Publication date 2003-01-01
Year available 2003
Sub-type Article (original research)
DOI 10.1375/136905203770326420
Open Access Status
Volume 6
Issue 5
Start page 422
End page 431
Total pages 10
Editor N. G. Martin
K. M. Kirk
Place of publication Bowen Hills, Australia
Publisher Australian Academic Press
Language eng
Subject C1
321011 Medical Genetics
730107 Inherited diseases (incl. gene therapy)
Abstract Migraine is a common neurovascular brain disorder that is manifested in recurrent episodes of disabling headache. The aim of the present study was to compare the prevalence and heritability of migraine across six of the countries that participate in GenomEutwin project including a total number of 29,717 twin pairs. Migraine was assessed by questionnaires that differed between most countries. It was most prevalent in Danish and Dutch females (32% and 34%, respectively), whereas the lowest prevalence was found in the younger and older Finnish cohorts (13% and 10%, respectively). The estimated genetic variance (heritability) was significant and the same between sexes in all countries. Heritability ranged from 34% to 57%, with lowest estimates in Australia, and highest estimates in the older cohort of Finland, the Netherlands, and Denmark. There was some indication that part of the genetic variance was non-additive, but this was significant in Sweden only. In addition to genetic factors, environmental effects that are non-shared between members of a twin pair contributed to the liability of migraine. After migraine definitions are homogenized among the participating countries, the GenomEUtwin project will provide a powerful resource to identify the genes involved in migraine.
Keyword Genetics & Heredity
Obstetrics & Gynecology
Reproductive Biology
Familial Hemiplegic Migraine
Ca2+ Channel Gene
Spreading Depression
Swedish Twin
Q-Index Code C1
Institutional Status Non-UQ

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Created: Wed, 15 Aug 2007, 05:32:28 EST