High frequency of BRAF mutations in nevi

Pollock, Pamela M., Harper, Ursula L., Hansen, Katherine S., Yudt, Laura M., Stark, Mitchell, Robbins, Christiane M., Moses, Tracy Y., Hostetter, Galen, Wagner, Urs, Kakareka, John, Salem, Ghadi, Pohida, Tom, Heenan, Peter, Duray, Paul, Kallioniemi, Olli, Hayward, Nicholas K., Trent, Jeffrey M. and Meltzer, Paul S. (2003) High frequency of BRAF mutations in nevi. Nature Genetics, 33 1: 19-20. doi:10.1038/ng1054


Author Pollock, Pamela M.
Harper, Ursula L.
Hansen, Katherine S.
Yudt, Laura M.
Stark, Mitchell
Robbins, Christiane M.
Moses, Tracy Y.
Hostetter, Galen
Wagner, Urs
Kakareka, John
Salem, Ghadi
Pohida, Tom
Heenan, Peter
Duray, Paul
Kallioniemi, Olli
Hayward, Nicholas K.
Trent, Jeffrey M.
Meltzer, Paul S.
Title High frequency of BRAF mutations in nevi
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1038/ng1054
Open Access Status Not yet assessed
Volume 33
Issue 1
Start page 19
End page 20
Total pages 2
Place of publication New York, United States
Publisher Nature America
Collection year 2003
Language eng
Subject 321011 Medical Genetics
730108 Cancer and related disorders
111201 Cancer Cell Biology
111203 Cancer Genetics
Abstract To evaluate the timing of mutations in BRAF (v-raf murine sarcoma viral oncogene homolog B1) during melanocytic neoplasia, we carried out mutation analysis on microdissected melanoma and nevi samples. We observed mutations resulting in the V599E amino-acid substitution in 41 of 60 (68%) melanoma metastases, 4 of 5 (80%) primary melanomas and, unexpectedly, in 63 of 77 (82%) nevi. These data suggest that mutational activation of the RAS/RAF/MAPK pathway in nevi is a critical step in the initiation of melanocytic neoplasia but alone is insufficient for melanoma tumorigenesis.
Q-Index Code CX
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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