Vitamin D and the brain: genomic and non-genomic actions

Cui, Xiaoying, Gooch, Helen, Petty, Alice, McGrath, John J. and Eyles, Darryl (2017) Vitamin D and the brain: genomic and non-genomic actions. Molecular and Cellular Endocrinology, 453 C: 131-143. doi:10.1016/j.mce.2017.05.035

Author Cui, Xiaoying
Gooch, Helen
Petty, Alice
McGrath, John J.
Eyles, Darryl
Title Vitamin D and the brain: genomic and non-genomic actions
Journal name Molecular and Cellular Endocrinology   Check publisher's open access policy
ISSN 1872-8057
Publication date 2017-06-01
Sub-type Article (original research)
DOI 10.1016/j.mce.2017.05.035
Open Access Status Not yet assessed
Volume 453
Issue C
Start page 131
End page 143
Total pages 13
Place of publication E Park, Shannon, Clare Ireland
Publisher Elsevier Ireland
Language eng
Formatted abstract
1,25(OH)2D3 (vitamin D) is well-recognized as a neurosteroid that modulates multiple brain functions. A growing body of evidence indicates that vitamin D plays a pivotal role in brain development, neurotransmission, neuroprotection and immunomodulation. However, the precise molecular mechanisms by which vitamin D exerts these functions in the brain are still unclear. Vitamin D signalling occurs via the vitamin D receptor (VDR), a zinc-finger protein in the nuclear receptor superfamily. Like other nuclear steroids, vitamin D has both genomic and non-genomic actions. The transcriptional activity of vitamin D occurs via the nuclear VDR. Its faster, non-genomic actions can occur when the VDR is distributed outside the nucleus. The VDR is present in the developing and adult brain where it mediates the effects of vitamin D on brain development and function. The purpose of this review is to summarise the in vitro and in vivo work that has been conducted to characterise the genomic and non-genomic actions of vitamin D in the brain. Additionally we link these processes to functional neurochemical and behavioural outcomes. Elucidation of the precise molecular mechanisms underpinning vitamin D signalling in the brain may prove useful in understanding the role this steroid plays in brain ontogeny and function.
Keyword Brain
Genomic and non-genomic action
Vitamin D
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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