Cell death in toxic nephropathies

Gobe, GC and Endre, ZH (2003) Cell death in toxic nephropathies. Seminars In Nephrology, 23 5: 416-424. doi:10.1016/S0270-9295(03)00085-8


Author Gobe, GC
Endre, ZH
Title Cell death in toxic nephropathies
Journal name Seminars In Nephrology   Check publisher's open access policy
ISSN 0270-9295
Publication date 2003-01-01
Year available 2003
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0270-9295(03)00085-8
Open Access Status
Volume 23
Issue 5
Start page 416
End page 424
Total pages 9
Editor N. A. Kurtzman
Place of publication Philadelphia, U.S.A.
Publisher W. B. Saunders
Language eng
Subject C1
321012 Nephrology and Urology
730115 Urogenital system and disorders
Abstract Toxic nephropathies cause acute and chronic renal failure, primarily as a result of injury to renal tubular epithelium. There is a well-known capacity in the renal nephron for the synchronous occurrence of both apoptosis and necrosis in toxic nephropathies. This has engendered interest in the differing or complementary roles of these modes of cell death. Once thought to be mutually exclusive in incidence and morphologic and biochemical features, recent evidence in renal and other diseases indicates some blurring in the features of apoptosis and necrosis, particularly in the situations in which they are identified, in their molecular pathways, and in the role of inflammation in the processes. Definition of the heterogenic pathophysiologic response of the nephron should provide information useful for promoting the health of the kidney after injury, particularly in relation to controlling the extent and modalities of cell death via the associated renal-specific molecular features. This article indicates the significance and some problems of defining the types of cell death in toxic nephropathies.
Keyword Urology & Nephrology
Acute-renal-failure
Ischemia-reperfusion
Induced Apoptosis
Tubular Atrophy
Growth-factors
Injury
Rat
Mechanisms
Pathogenesis
Mitochondria
Q-Index Code C1
Institutional Status UQ
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 05:19:18 EST