Th1 cytokines in oral lichen planus

Khan, Ambereen, Farah, Camile S., Savage, Neil W., Walsh, Laurence J., Harbrow, Doug J. and Sugerman, Philip B. (2003) Th1 cytokines in oral lichen planus. Journal of Oral Pathology and Medicine, 32 2: 77-83. doi:10.1034/j.1600-0714.2003.00077.x

Author Khan, Ambereen
Farah, Camile S.
Savage, Neil W.
Walsh, Laurence J.
Harbrow, Doug J.
Sugerman, Philip B.
Title Th1 cytokines in oral lichen planus
Journal name Journal of Oral Pathology and Medicine   Check publisher's open access policy
ISSN 0904-2512
Publication date 2003-02-01
Year available 2003
Sub-type Article (original research)
DOI 10.1034/j.1600-0714.2003.00077.x
Open Access Status Not yet assessed
Volume 32
Issue 2
Start page 77
End page 83
Total pages 7
Editor E. Dabelsteen
Place of publication Copenhagen
Publisher Blackwell Munksgaard
Language eng
Subject C1
320899 Dentistry not elsewhere classified
730112 Oro-dental and disorders
Abstract Background: Cell-mediated immune responses in oral lichen planus (OLP) may be regulated by cytokines and their receptors. Methods: In situ cytokine expression and in vitro cytokine secretion in OLP were determined by immunohistochemistry and ELISA. Resulults: The majority of subepithelial and intraepithelial mononuclear cells in OLP were CD8(+) . In some cases, intraepithelial CD8(+) cells were adjacent to degenerating keratinocytes. CD4(+) cells were observed mainly in the deep lamina propria with occasional CD4(+) cells close to basal keratinocytes. Mononuclear cells expressed IFN-gamma in the superficial lamina propria and TNF-alpha adjacent to basal keratinocytes. Basal keratinocytes expressed TNF-alpha as a continuous band. TNF R1 was expressed by mononuclear cells and basal and suprabasal keratinocytes. There was variable expression of TGF-beta1 in the subepithelial infiltrate while all intraepithelial mononuclear cells were TGF-beta1(-) . Keratinocytes in OLP stained weakly for TGF-beta1. Unstimulated OLP lesional T cells secreted IFN-gammain vitro . TNF-alpha stimulation down-regulated IFN-gamma secretion and up-regulated TNF-alpha secretion. IL-4, IL-10 and TGF-beta1 secretion were not detected. Conclusions: These data suggest the development of a T helper 1 immune response that may promote CD8(+) cytotoxic T-cell activity in OLP.
Keyword Dentistry, Oral Surgery & Medicine
Oral Lichen Planus
T-cell Subsets
Langerhans Cells
Targeted Disruption
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Dentistry Publications
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Citation counts: TR Web of Science Citation Count  Cited 120 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 136 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 05:08:37 EST