Equine laminitis: Cryotherapy reduces the severity of the acute lesion

Van Eps, A. W. and Pollitt, C. C. (2004) Equine laminitis: Cryotherapy reduces the severity of the acute lesion. Equine Veterinary Journal, 36 3: 255-260. doi:10.2746/0425164044877107

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Author Van Eps, A. W.
Pollitt, C. C.
Title Equine laminitis: Cryotherapy reduces the severity of the acute lesion
Journal name Equine Veterinary Journal   Check publisher's open access policy
ISSN 0425-1644
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.2746/0425164044877107
Volume 36
Issue 3
Start page 255
End page 260
Total pages 6
Place of publication Fordham, Cambs, U.K,
Publisher Equine Veterinary Journal
Language eng
Subject 0707 Veterinary Sciences
Formatted abstract
Reasons for performing study: The hypometabolic and vasoconstrictive effects of cryotherapy could prevent the development of laminitis.

Objectives: To use distal limb cryotherapy to prevent laminitis induced by alimentary carbohydrate overload.

Methods: Laminitis was induced in 6 Standardbred horses that had one front limb continuously cooled in an ice/water mixture. Lameness evaluation, blinded lamellar histological grading and analysis for lamellar matrix metalloproteinase-2 (MMP-2) mRNA expression were used to evaluate the severity of laminitis.

Results: Cryotherapy was well tolerated and effective in cooling the feet. In each horse no lameness was observed in the treated limbs. Laminitis histology scores in the treated limbs were significantly less than those of the corresponding untreated forelimbs (P<0.05). Laminitis histology scores in the treated limbs were also significantly less than those of the untreated limbs (fore- and hind) as a group (P<0.05). Expression of MMP-2 mRNA in the iced feet was significantly (P<0.05) less than that detected in the untreated feet.

Conclusions: Cryotherapy, when applied to one foot, markedly reduced the severity of acute laminitis in this study. We propose that vasoconstriction (preventing delivery of haematogenous trigger factors) and hypometabolism (reduction in lamellar MMP activity) were the primary therapeutic mechanisms.

Potential relevance: Although further research is needed, we suggest cryotherapy as a potentially effective prophylactic strategy in horses at risk of developing acute laminitis.

Keyword Horse
Q-Index Code C1
Additional Notes Laminitis Special Issue

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Veterinary Science Publications
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Created: Wed, 01 Mar 2006, 21:31:14 EST