Role of PGF(2 alpha) and oxytocin in parturition in the brushtail possum (Trichosurus vulpecula)

Veitch, C., Brown, L., Sernia, C. and Gemmell, R. T. (2002) Role of PGF(2 alpha) and oxytocin in parturition in the brushtail possum (Trichosurus vulpecula). Reproduction, 123 3: 429-434. doi:10.1530/rep.0.1230429

Author Veitch, C.
Brown, L.
Sernia, C.
Gemmell, R. T.
Title Role of PGF(2 alpha) and oxytocin in parturition in the brushtail possum (Trichosurus vulpecula)
Journal name Reproduction   Check publisher's open access policy
ISSN 1470-1626
Publication date 2002-03-01
Sub-type Article (original research)
DOI 10.1530/rep.0.1230429
Open Access Status DOI
Volume 123
Issue 3
Start page 429
End page 434
Total pages 6
Editor Dr CA Doberska
Place of publication UK
Publisher Society for Reproduction - Fertility
Language eng
Subject C1
320603 Systems Physiology
730116 Reproductive system and disorders
Abstract Maturation of the fetal pituitary and adrenal glands allows the secretion of cortisol, which in turn leads to an increase in prostaglandin and mesotocin production. The production of prostaglandin and mesotocin results in an increase in uterine contractions and initiates birth in marsupials. The major metabolite of PGF(2alpha), 13,14-dihydro-15-keto-prostaglandin F-2alpha (PGFM), has been found in the plasma of the possum at the time of birth and administration of PGF(2alpha) to female possums induced the adoption of the birth position. Evidence that mesotocin is an integral hormone of birth in the tammar wallaby indicates that both PGF(2alpha) and mesotocin or oxytocin are required for marsupial birth. The presence of PGF(2alpha) receptors in the uterus and corpus luteum of the possum, and the in vitro uterine responsiveness to PGF(2alpha) or oxytocin, were examined. PGF(2alpha) receptors were not observed in possum uteri and the inability of PGF(2alpha) to cause contractions indicates that PGF(2alpha) is not involved directly in contraction of the uterus at parturition. The presence of oxytocin and mesotocin receptors in the uterus of possoms and the ability of oxytocin to induce uterine contraction in vitro supports the view that mesotocin is required for expulsion of the young from the uterus. Low numbers of PGF(2alpha) receptors were found in the possum corpus luteum at birth, indicating an involvement of PGF(2alpha) in regression of the corpus luteum.
Keyword Developmental Biology
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 05:03:33 EST