Diverse synaptic mechanisms generate direction selectivity in the rabbit retina

Rowland Taylor, W. and Vaney, D. I. (2002) Diverse synaptic mechanisms generate direction selectivity in the rabbit retina. Journal of Neuroscience, 22 17: 7712-7720.

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Author Rowland Taylor, W.
Vaney, D. I.
Title Diverse synaptic mechanisms generate direction selectivity in the rabbit retina
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2002-09-01
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 22
Issue 17
Start page 7712
End page 7720
Total pages 9
Editor D. Van Essen
Place of publication USA
Publisher Society for Neuroscience
Language eng
Subject C1
320702 Central Nervous System
730111 Hearing, vision, speech and their disorders
110903 Central Nervous System
Abstract The synaptic conductance of the On-Off direction-selective ganglion cells was measured during visual stimulation to determine whether the direction selectivity is a property of the circuitry presynaptic to the ganglion cells or is generated by postsynaptic interaction of excitatory and inhibitory inputs. Three synaptic asymmetries were identified that contribute to the generation of direction-selective responses: (1) a presynaptic mechanism producing stronger excitation in the preferred direction, (2) a presynaptic mechanism producing stronger inhibition in the opposite direction, and (3) postsynaptic interaction of excitation with spatially offset inhibition. Although the on- and off-responses showed the same directional tuning, the off-response was generated by all three mechanisms, whereas the on- response was generated primarily by the two presynaptic mechanisms. The results indicate that, within a single neuron, different strategies are used within distinct dendritic arbors to accomplish the same neural computation.
Keyword Direction Selectivity
Ganglion Cells
Synaptic Conductance
Dendritic Integration
On- And Off-pathways
Rabbit Retina
Starburst Amacrine Cells
Dendritic Architecture
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 127 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 131 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 05:02:50 EST