Distribution of two splice variants of the glutamate transporter GLT-1 in the developing rat retina

Reye, P, Sullivan, R and Pow, DV (2002) Distribution of two splice variants of the glutamate transporter GLT-1 in the developing rat retina. Journal of Comparative Neurology, 447 4: 323-330. doi:10.1002/cne.10218


Author Reye, P
Sullivan, R
Pow, DV
Title Distribution of two splice variants of the glutamate transporter GLT-1 in the developing rat retina
Journal name Journal of Comparative Neurology   Check publisher's open access policy
ISSN 0021-9967
Publication date 2002-01-01
Year available 2002
Sub-type Article (original research)
DOI 10.1002/cne.10218
Open Access Status
Volume 447
Issue 4
Start page 323
End page 330
Total pages 8
Editor Sanford L Palay
Place of publication USA
Publisher John Wiley & Sons, Inc
Language eng
Subject C1
320705 Sensory Systems
730111 Hearing, vision, speech and their disorders
Abstract The distributions of a carboxyl terminal splice variant of the glutamate transporter GLT-1, referred to as GLT-1B, and the carboxyl terminus of the originally described variant of GLT-1, referred to hereafter as GLT-1alpha, were examined using specific antisera. GLT-1B was present in the retina at very early developmental stages. Labelling was demonstrable at embryonic day 14, and strong labelling was evident by embryonic day 18. Such labelling was initially restricted to populations of cone photoreceptors, the processes of which extended through the entire thickness of the retina and appeared to make contact with the retinal ganglion cells. During postnatal development the GLT-1B-positive photoreceptor processes retracted to form the outer plexiform layer, and around postnatal day 7, GLT-1B-immunoreactive bipolar cells appeared. The pattern of labelling of bipolar cell processes within the inner plexiform layer changed during postnatal development. Two strata of strongly immunoreactive terminals were initially evident in the inner plexiform layer, but by adulthood these two bands were no longer evident and labelling was restricted to the somata and processes (but not synaptic terminals) of the bipolar cells, as well as the somata, processes, and terminals of cone photoreceptors. By contrast, GLT-1alpha appeared late in postnatal development and was restricted mainly to a population of amacrine cells, although transient labelling was also associated with punctate elements in the outer plexiform layer, which may represent photoreceptor terminals, (C) 2002 Wiley-Liss, Inc.
Keyword Neurosciences
Zoology
Amacrine
Antibody
Bipolar Cell
Cone Photoreceptor
Rod Photoreceptor
Synaptogenesis
Rod Photoreceptor Differentiation
Expression
Localization
Glycine
Glyt-1
Glast
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Wed, 15 Aug 2007, 05:02:42 EST