Complementary and layered expression of Ephs and Ephrins in developing mouse inner ear

Pickles, James O., Claxton, Christina and van Heumen, Walter R. A. (2002) Complementary and layered expression of Ephs and Ephrins in developing mouse inner ear. Journal of Comparative Neurology, 449 3: 207-216. doi:10.1002/cne.10231


Author Pickles, James O.
Claxton, Christina
van Heumen, Walter R. A.
Title Complementary and layered expression of Ephs and Ephrins in developing mouse inner ear
Journal name Journal of Comparative Neurology   Check publisher's open access policy
ISSN 1096-9861
0021-9967
Publication date 2002-06-20
Sub-type Article (original research)
DOI 10.1002/cne.10231
Volume 449
Issue 3
Start page 207
End page 216
Total pages 10
Editor Sunford L. Palay
Place of publication Hoboken, New Jersey, U.S.A.
Publisher John Wiley & Sons Inc
Language eng
Subject C1
270602 Animal Physiology - Cell
780105 Biological sciences
06 Biological Sciences
0606 Physiology
Abstract The distributions of the Eph-class receptors EphA4 and EphB 1, and their ligands ephrin-A2, ephrin-B1, and ephrin-B2, were analysed by immunostaining in the mouse inner ear. Complementary patterns of EphA4 and its potential ligand ephrin-A2 were found, with ephrin-A2 in many of the structures lining the cochlear duct and within the cochlear nerve cells, and EphA4 in the deeper structures underlying the cochlear duct and in the cells lining the nerve pathway. EphB1 and its potential ligands ephrin-B1 and ephrin-B2 showed a segregated layered expression in the lateral wall of the cochlear duct (the external sulcus), which together with EphA4 expressed in the area, form a four-layered structure with an alternating pattern of receptors and ligands in the different layers. This arrangement gives the potential for different bidirectional Eph-mediated interactions between each of the layers. The results suggest that the Eph system in the cochlea may have a role in maintaining cell segregation during phases of cochlear development. (C) 2002 Wiley-Liss, Inc.
Keyword Neurosciences
Zoology
Epha4
Ephb1
Ephrin-a2
Ephrin-b1
Ephrin-b2
Cochlea
Hair Cells
Spiral Ganglion
Cell Segregation
Development
Receptor Tyrosine Kinases
Neural Crest Migration
Ligands
Projection
Guidance
Family
Embryogenesis
Organization
Hindbrain
Distinct
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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Created: Wed, 15 Aug 2007, 05:02:29 EST