Therapeutic potential of selective superoxide dismutase mimetics

Doggrell, Sheila A. (2002) Therapeutic potential of selective superoxide dismutase mimetics. Drugs of The Future, 27 4: 385-390. doi:10.1358/dof.2002.027.04.664560


Author Doggrell, Sheila A.
Title Therapeutic potential of selective superoxide dismutase mimetics
Journal name Drugs of The Future   Check publisher's open access policy
ISSN 0377-8282
Publication date 2002-04-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1358/dof.2002.027.04.664560
Volume 27
Issue 4
Start page 385
End page 390
Total pages 6
Place of publication Spain
Publisher Prous Science
Language eng
Subject CX
320503 Clinical Pharmacology and Therapeutics
730199 Clinical health not specific to particular organs, diseases and conditions
Abstract Selective superoxide dismutase (SOD) mimetics are potentially useful in pathological conditions in which there is an overproduction of the superoxide anion O-2.(-). These pathological conditions include inflammation, ischemia/reperfusion, shock, various cardiovascular disorders, amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. A major step forward in this field was the development of small-molecule selective SOD mimetics that penetrate cell membranes, These selective SOD mimetics catalytically remove O-2.(-) without interfering with nitric oxide (NO), peroxynitrite (ONOO-) or other radicals such as hydroxyl radical or hydrogen peroxide (H2O2). These selective SOD mimetics (SC-52608, SC-55858, M-40403 and M-40401) have been shown to have benefits in animal models of inflammation, ischemia/reperfusion, shock, thrombosis and diabetes. The next challenge with selective SOD mimetics is to develop therapeutic potential into therapeutic agents.
Keyword Pharmacology & Pharmacy
Reperfusion Injury
Catalytic Activity
In-vivo
M40403
Complexes
Rats
Pathogenesis
Design
Damage
Shock
Q-Index Code CX

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 04:59:41 EST