NPS-2143 - Treatment of osteoporosis - Calcilytic

Doggrell, Sheila A., del Fresno, M. and Castaner, J. (2002) NPS-2143 - Treatment of osteoporosis - Calcilytic. Drugs of The Future, 27 2: 140-142. doi:10.1358/dof.2002.027.02.656406


Author Doggrell, Sheila A.
del Fresno, M.
Castaner, J.
Title NPS-2143 - Treatment of osteoporosis - Calcilytic
Journal name Drugs of The Future   Check publisher's open access policy
ISSN 0377-8282
Publication date 2002-02-01
Sub-type Article (original research)
DOI 10.1358/dof.2002.027.02.656406
Volume 27
Issue 2
Start page 140
End page 142
Total pages 3
Place of publication Spain
Publisher Prous Science
Language eng
Subject CX
320502 Basic Pharmacology
730114 Skeletal system and disorders (incl. arthritis)
Abstract Efforts to discover new treatments for osteoporosis led to the identification of the potent and selective, small-molecule calcium receptor antagonist NPS-2143. NPS-2143 is the prototype calcilytic drug, designed to act on calcium receptors on the surface of parathyroid glands, stimulating the release of the body's own stores of native parathyroid hormone (PTH). In osteopenic ovariectomized rats, daily oral administration of NPS-2143 resulted in moderate but sustained increases in plasma PTH levels and marked increases in bone formation and resorption, with no net bone gain or loss. The combination of NPS-2143 and estrogen increases bone formation and density to a greater extent than either agent alone. These results suggest that NPS-2143 may be useful in the treatment of established osteoporosis.
Keyword Pharmacology & Pharmacy
Sb-262470
Parathyroid-hormone
Secretion
Receptor
Bone
Rats
Q-Index Code CX

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 04:59:35 EST