Opposing roles for medial and central amygdala in the initiation of noradrenergic cell responses to a psychological stressor

Dayas, C.V. and Day, T.A. (2002) Opposing roles for medial and central amygdala in the initiation of noradrenergic cell responses to a psychological stressor. European Journal of Neuroscience, 15 10: 1712-1718. doi:10.1046/j.1460-9568.2001.02011.x


Author Dayas, C.V.
Day, T.A.
Title Opposing roles for medial and central amygdala in the initiation of noradrenergic cell responses to a psychological stressor
Journal name European Journal of Neuroscience   Check publisher's open access policy
ISSN 0953-816X
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1046/j.1460-9568.2001.02011.x
Volume 15
Issue 10
Start page 1712
End page 1718
Total pages 7
Editor B.J. Everitt
Place of publication Oxford, England
Publisher Blackwell Publishing Ltd.
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract Psychological stressors trigger the activation of medullary noradrenergic cells, an effect that has been shown to depend upon yet-to-be-identified structures located higher in the brain. To test whether the amygdala is important in this regard, we examined the effects of amygdala lesions on noradrenergic cell responses to restraint, and also looked at whether any amygdala cells that respond to restraint project directly to the medulla. Ibotenic acid lesions of the medial amygdala completely abolished restraint-induced Fos expression in A1 and A2 noradrenergic cells. In contrast, lesions of the central amygdala actually facilitated noradrenergic cell responses to restraint. Tracer deposits in the dorsomedial (but not ventrolateral) medulla retrogradely labelled many cells in the central nucleus of the amygdala, but none of these cells expressed Fos in response to restraint. These data suggest for the first time that the medial amygdala is critical to the activation of medullary noradrenergic cells by a psychological stressor whereas the central nucleus exerts an opposing, inhibitory influence upon noradrenergic cell recruitment. The initiation of noradrenergic cell responses by the medial amygdala does not involve a direct projection to the medulla. Accordingly, a relay through some other structure, such as the hypothalamic paraventricular nucleus, warrants careful consideration.
Keyword Neurosciences
A1 Cells
A2 Cells
Amygdala
Restraint
Stress
Hypothalamic Paraventricular Nucleus
Inhibitory-type Synapses
Brain-stem
Emotional Stressor
Neurons
Rat
Organization
Projections
Immunoreactivity
Stimulation
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Wed, 15 Aug 2007, 04:58:48 EST