Resistance to antiparasitic drugs: The role of molecular diagnosis

Sangster, N., Batterham, P., Chapman, H. D., Duraisingh, M., Le Jambre, L., Shirley, M., Upcroft, J. and Upcroft, P. (2002) Resistance to antiparasitic drugs: The role of molecular diagnosis. International Journal For Parasitology, 32 5: 637-653. doi:10.1016/S0020-7519(01)00365-4

Author Sangster, N.
Batterham, P.
Chapman, H. D.
Duraisingh, M.
Le Jambre, L.
Shirley, M.
Upcroft, J.
Upcroft, P.
Title Resistance to antiparasitic drugs: The role of molecular diagnosis
Journal name International Journal For Parasitology   Check publisher's open access policy
ISSN 0020-7519
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1016/S0020-7519(01)00365-4
Volume 32
Issue 5
Start page 637
End page 653
Total pages 17
Place of publication United Kingdom
Publisher Elsevier Science Ltd
Language eng
Subject C1
321206 Preventive Medicine
730213 Preventive medicine
1108 Medical Microbiology
Abstract Chemotherapy is central to the control of many parasite infections of both medical and veterinary importance. However, control has been compromised by the emergence of drug resistance in several important parasite species. Such parasites cover a broad phylogenetic range and include protozoa, helminths and arthropods. In order to achieve effective parasite control in the future, the recognition and diagnosis of resistance will be crucial. This demand for early, accurate diagnosis of resistance to specific drugs in different parasite species can potentially be met by modern molecular techniques. This paper summarises the resistance status of a range of important parasites and reviews the available molecular techniques for resistance diagnosis. Opportunities for applying successes in some species to other species where resistance is less well understood are explored. The practical application of molecular techniques and the impact of the technology on improving parasite control are discussed. (C) 2002 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.
Keyword Parasitology
Drug Resistance
Polymerase Chain-reaction
Ethyl Methanesulfonate Mutagenesis
Falciparum Dihydrofolate-reductase
Drosophila-melanogaster Diptera
Dihydropteroate Synthetase Gene
Lucilia-cuprina Diptera
Beta-tubulin Isotype-1
Anthelmintic Resistance
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 32 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 04:57:17 EST