Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives

Kazimierczuk, Zygmunt, Upcroft, Jacqueline A., Upcroft, Peter, Gorska, Agata, Starosciak, Bohdan and Laudy, Agnieszka (2002) Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives. Acta Biochimica Polonica, 49 1: 185-195.

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Author Kazimierczuk, Zygmunt
Upcroft, Jacqueline A.
Upcroft, Peter
Gorska, Agata
Starosciak, Bohdan
Laudy, Agnieszka
Title Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives
Journal name Acta Biochimica Polonica   Check publisher's open access policy
ISSN 0001-527X
Publication date 2002-01-01
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 49
Issue 1
Start page 185
End page 195
Total pages 11
Editor L. Konarska
Place of publication Warsaw, Poland
Publisher Poliskie Towarzystwo Biochemiczne
Collection year 2002
Language eng
Subject C1
321206 Preventive Medicine
730213 Preventive medicine
Abstract Two series of benzimidazole derivatives were sythesised. The first one was based on 5,6-dinitrobenzimidazole, the second one comprises 2-thioalkyl- and thioaryl-substituted modified benzimidazoles. Antibacterial and antiprotozoal. activity of the newly obtained compounds was studied. Some thioalkyl derivatives showed remarkable activity against nosocomial strains of Stenotrophomonas malthophilia, and an activity comparable to that of metronidazole against Gram-positive and Gram-negative bacteria. Of the tested compounds, 5,6-dichloro-2-(4-nitrobenzylthio)-benzimidazole showed the most distinct antiprotozoal activity.
Keyword Biochemistry & Molecular Biology
Benzimidazoles
Antiprotozoal Activity
Antibacterial Activity
Antimicrobial Activity
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Wed, 15 Aug 2007, 04:50:04 EST