Lipoamino acid-based adjuvant carrier system: Enhanced immunogenicity of group a streptococcal peptide epitopes

Horvath, Aniko, Olive, Colleen, Wong, Allan, Clair, Timothy, Yarwood, Penny, Good, Michael and Toth, Istvan (2002) Lipoamino acid-based adjuvant carrier system: Enhanced immunogenicity of group a streptococcal peptide epitopes. Journal of Medicinal Chemistry, 45 6: 1387-1390. doi:10.1021/jm0110441


Author Horvath, Aniko
Olive, Colleen
Wong, Allan
Clair, Timothy
Yarwood, Penny
Good, Michael
Toth, Istvan
Title Lipoamino acid-based adjuvant carrier system: Enhanced immunogenicity of group a streptococcal peptide epitopes
Journal name Journal of Medicinal Chemistry   Check publisher's open access policy
ISSN 0022-2623
Publication date 2002-01-01
Year available 2002
Sub-type Article (original research)
DOI 10.1021/jm0110441
Open Access Status Not yet assessed
Volume 45
Issue 6
Start page 1387
End page 1390
Total pages 4
Editor P. S. Portoghese
Place of publication Washington
Publisher American Chemical Society
Language eng
Subject C1
730213 Preventive medicine
321206 Preventive Medicine
Abstract Lipoamino acid-based synthetic peptides (lipid core peptides, LCP) derived from the type-specific and conserved region determinants of group A streptococci (GAS) were evaluated as potential candidate sequences in a vaccine to prevent GAS-associated diseases, including rheumatic heart, disease and poststreptococcal acute glomerulonephritis. The LCP peptides had significantly enhanced immunogenicity as compared with the monomeric peptide epitopes. Furthermore, the peptides incorporated into the LCP system generated epitope-specific antibodies without the use of any conventional adjuvant.
Keyword Chemistry, Medicinal
Group-a Streptococci
Lipidic Amino-acids
M-protein Vaccine
B-cell Epitopes
Synthetic Peptide
Mouth-disease
Mucosal Colonization
Rheumatic-fever
T-cell
Recombinant
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Pharmacy Publications
 
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Created: Wed, 15 Aug 2007, 04:45:35 EST