D2 dopamine receptor gene polymorphism discriminates two kinds of novelty seeking

Berman, S, Ozkaragoz, T, Young, RM and Noble, EP (2002) D2 dopamine receptor gene polymorphism discriminates two kinds of novelty seeking. Personality And Individual Differences, 33 6: 867-882. doi:10.1016/S0191-8869(01)00197-0

Author Berman, S
Ozkaragoz, T
Young, RM
Noble, EP
Title D2 dopamine receptor gene polymorphism discriminates two kinds of novelty seeking
Journal name Personality And Individual Differences   Check publisher's open access policy
ISSN 0191-8869
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1016/S0191-8869(01)00197-0
Open Access Status Not Open Access
Volume 33
Issue 6
Start page 867
End page 882
Total pages 16
Place of publication UK
Publisher Pergamon
Language eng
Subject C1
321021 Psychiatry
730211 Mental health
Abstract Cloninger's psychobiological model of personality as applied to substance misuse has received mixed support. Contrary to the model, recent data suggest that a combination of high novelty seeking (NS) and high harm avoidance (HA) represents a significant risk for the development of severe substance misuse. A genetic polymorphism previously implicated in severe substance dependence, the A1 allele of the D2 dopamine receptor (DRD2) gene, was examined in relation to NS and HA amongst 203 adolescent boys. Specifically, we hypothesized that subjects with the A1 + allele (A1/A1 and A1/A2 genotypes) would report stronger NS and would exhibit a more positive relationship between NS and HA than those with the A1-allele (A2/A2 genotypes). These predictions were supported. The correlation between NS and HA in 81 A1 + allelic boys (r = 0.27, P = 0.02), and that in the 122 A1- allelic boys (r = -0.15, P = 0.09), indicated that this relationship differed according to allelic status (F = 8.52, P < 0:004). Among those with the A1-allele, the present results are consistent with the traditional view that novelty seeking provides positive reinforcement, or the fulfillment of appetitive drives. In contrast, novelty seeking in those with the A1 + allele appears to include a negative reinforcement or self-medicating function. (C) 2002 Elsevier Science Ltd. All rights reserved.
Keyword Psychology, Social
D2 Dopamine Receptor Gene
Novelty Seeking
Harm Avoidance
Tridimensional Personality Questionnaire
Substance Use Disorders
Allelic Association
A1 Allele
Character Inventory
Cognitive Functions
Risk Factor
Drd2 Gene
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 34 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 39 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 04:45:17 EST