The effects of tamoxifen on plasma lipoprotein(a) concentrations: systematic review and meta-analysis

Sahebkar, Amirhossein, Serban, Maria-Corina, Penson, Peter, Gurban, Camelia, Ursoniu, Sorin, Toth, Peter P., Jones, Steven R., Lippi, Giuseppe, Kotani, Kazuhiko, Kostner, Karam, Rizzo, Manfredi, Rysz, Jacek and Banach, Maciej (2017) The effects of tamoxifen on plasma lipoprotein(a) concentrations: systematic review and meta-analysis. Drugs, 77 11: 1187-1197. doi:10.1007/s40265-017-0767-4


Author Sahebkar, Amirhossein
Serban, Maria-Corina
Penson, Peter
Gurban, Camelia
Ursoniu, Sorin
Toth, Peter P.
Jones, Steven R.
Lippi, Giuseppe
Kotani, Kazuhiko
Kostner, Karam
Rizzo, Manfredi
Rysz, Jacek
Banach, Maciej
Title The effects of tamoxifen on plasma lipoprotein(a) concentrations: systematic review and meta-analysis
Journal name Drugs   Check publisher's open access policy
ISSN 1179-1950
0012-6667
Publication date 2017-06-01
Sub-type Article (original research)
DOI 10.1007/s40265-017-0767-4
Open Access Status DOI
Volume 77
Issue 11
Start page 1187
End page 1197
Total pages 11
Place of publication Auckland, New Zealand
Publisher Springer International Publishing
Language eng
Subject 2736 Pharmacology (medical)
Abstract Tamoxifen is a selective estrogen receptor modulator widely used in the treatment of breast cancer. Tamoxifen therapy is associated with lower circulating low-density lipoprotein cholesterol and increased triglycerides, but its effects on other lipids are less well studied.
Formatted abstract
Introduction: Tamoxifen is a selective estrogen receptor modulator widely used in the treatment of breast cancer. Tamoxifen therapy is associated with lower circulating low-density lipoprotein cholesterol and increased triglycerides, but its effects on other lipids are less well studied.

Aims: We aimed to investigate the effect of tamoxifen on circulating concentrations of lipoprotein(a) [Lp(a)] through a meta-analysis of available randomized controlled trials (RCTs) and observational studies.

Methods: This study was registered in the PROSPERO database (CRD42016036890). Scopus, MEDLINE and EMBASE were searched from inception until 22 March 2016 to identify studies investigating the effect of tamoxifen on Lp(a) values in humans. Meta-analysis was performed using an inverse variance-weighted, random-effects model with standardized mean difference (SMD) as the effect size estimate.

Results: Meta-analysis of five studies with 215 participants suggested a statistically significant reduction of Lp(a) levels following tamoxifen treatment (SMD −0.41, 95% confidence interval −0.68 to −0.14, p = 0.003). This effect was robust in the sensitivity analysis.

Conclusions: Meta-analysis suggested a statistically significant reduction of Lp(a) levels following tamoxifen treatment. Further well-designed trials are required to validate these results.
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
HERDC Pre-Audit
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 20 Jun 2017, 00:03:31 EST by System User on behalf of Learning and Research Services (UQ Library)