Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group

Renteria, M. E., Schmaal, L., Hibar, D. P., Couvy-Duchesne, B., Strike, L. T., Mills, N. T., de Zubicaray, G. I., McMahon, K. L., Medland, S. E., Gillespie, N. A., Hatton, S. N., Lagopoulos, J., Veltman, D. J., van der Wee, N., van Erp, T. G. M., Wittfeld, K., Grabe, H. J., Block, A., Hegenscheid, K., Voelzke, H., Veer, I. M., Walter, H., Schnell, K., Schramm, E., Normann, C., Schoepf, D., Konrad, C., Zurowski, B., Godlewska, B. R., Cowen, P. J., Penninx, B. W. J. H., Jahanshad, N., Thompson, P. M., Wright, M. J., Martin, N. G., Christensen, H. and Hickie, I. B. (2017) Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group. Translational Psychiatry, 7 5: . doi:10.1038/tp.2017.84


Author Renteria, M. E.
Schmaal, L.
Hibar, D. P.
Couvy-Duchesne, B.
Strike, L. T.
Mills, N. T.
de Zubicaray, G. I.
McMahon, K. L.
Medland, S. E.
Gillespie, N. A.
Hatton, S. N.
Lagopoulos, J.
Veltman, D. J.
van der Wee, N.
van Erp, T. G. M.
Wittfeld, K.
Grabe, H. J.
Block, A.
Hegenscheid, K.
Voelzke, H.
Veer, I. M.
Walter, H.
Schnell, K.
Schramm, E.
Normann, C.
Schoepf, D.
Konrad, C.
Zurowski, B.
Godlewska, B. R.
Cowen, P. J.
Penninx, B. W. J. H.
Jahanshad, N.
Thompson, P. M.
Wright, M. J.
Martin, N. G.
Christensen, H.
Hickie, I. B.
Title Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group
Journal name Translational Psychiatry   Check publisher's open access policy
ISSN 2158-3188
Publication date 2017-05-01
Year available 2017
Sub-type Article (original research)
DOI 10.1038/tp.2017.84
Open Access Status DOI
Volume 7
Issue 5
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 2738 Psychiatry and Mental health
2804 Cellular and Molecular Neuroscience
2803 Biological Psychiatry
Abstract The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging methods provide a noninvasive approach to explore the neural correlates of suicide vulnerability in vivo. The ENIGMA-MDD Working Group is an international collaboration evaluating neuroimaging and clinical data from thousands of individuals collected by research groups from around the world. Here we present analyses in a subset sample (n = 3097) for whom suicidality data were available. Prevalence of suicidal symptoms among major depressive disorder (MDD) cases ranged between 29 and 69% across cohorts. We compared mean subcortical grey matter volumes, lateral ventricle volumes and total intracranial volume (ICV) in MDD patients with suicidal symptoms (N = 451) vs healthy controls (N = 1996) or MDD patients with no suicidal symptoms (N = 650). MDD patients reporting suicidal plans or attempts showed a smaller ICV (P = 4.12 x 10(-3)) or a 2.87% smaller volume compared with controls (Cohen's d = -0.284). In addition, we observed a nonsignificant trend in which MDD cases with suicidal symptoms had smaller subcortical volumes and larger ventricular volumes compared with controls. Finally, no significant differences (P = 0.28-0.97) were found between MDD patients with and those without suicidal symptoms for any of the brain volume measures. This is by far the largest neuroimaging meta-analysis of suicidal behaviour in MDD to date. Our results did not replicate previous reports of association between subcortical brain structure and suicidality and highlight the need for collecting better-powered imaging samples and using improved suicidality assessment instruments.
Formatted abstract
The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging methods provide a noninvasive approach to explore the neural correlates of suicide vulnerability in vivo. The ENIGMA-MDD Working Group is an international collaboration evaluating neuroimaging and clinical data from thousands of individuals collected by research groups from around the world. Here we present analyses in a subset sample (n=3097) for whom suicidality data were available. Prevalence of suicidal symptoms among major depressive disorder (MDD) cases ranged between 29 and 69% across cohorts. We compared mean subcortical grey matter volumes, lateral ventricle volumes and total intracranial volume (ICV) in MDD patients with suicidal symptoms (N=451) vs healthy controls (N=1996) or MDD patients with no suicidal symptoms (N=650). MDD patients reporting suicidal plans or attempts showed a smaller ICV (P=4.12 × 10−3) or a 2.87% smaller volume compared with controls (Cohen’s d=−0.284). In addition, we observed a nonsignificant trend in which MDD cases with suicidal symptoms had smaller subcortical volumes and larger ventricular volumes compared with controls. Finally, no significant differences (P=0.28–0.97) were found between MDD patients with and those without suicidal symptoms for any of the brain volume measures. This is by far the largest neuroimaging meta-analysis of suicidal behaviour in MDD to date. Our results did not replicate previous reports of association between subcortical brain structure and suicidality and highlight the need for collecting better-powered imaging samples and using improved suicidality assessment instruments.
Keyword Mood Disorders
Self-Harm
Risk
Adolescents
Ideation
Population
Family
Twins
Age
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
Centre for Advanced Imaging Publications
 
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