MR image-based measurement of rates of change in volumes of brain structures. Part 1: Method and validation

Wang, D. M. and Doddrell, D. M. (2002) MR image-based measurement of rates of change in volumes of brain structures. Part 1: Method and validation. Magnetic Resonance Imaging, 20 1: 27-40. doi:10.1016/S0730-725X(02)00466-6

Author Wang, D. M.
Doddrell, D. M.
Title MR image-based measurement of rates of change in volumes of brain structures. Part 1: Method and validation
Journal name Magnetic Resonance Imaging   Check publisher's open access policy
ISSN 0730-725X
ISBN 0730-725x
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1016/S0730-725X(02)00466-6
Open Access Status Not yet assessed
Volume 20
Issue 1
Start page 27
End page 40
Total pages 14
Place of publication New York
Publisher Elsevier Science Inc
Language eng
Subject C1
291599 Biomedical Engineering not elsewhere classified
730305 Diagnostic methods
Abstract A detailed analysis procedure is described for evaluating rates of volumetric change in brain structures based on structural magnetic resonance (MR) images. In this procedure, a series of image processing tools have been employed to address the problems encountered in measuring rates of change based on structural MR images. These tools include an algorithm for intensity non-uniforniity correction, a robust algorithm for three-dimensional image registration with sub-voxel precision and an algorithm for brain tissue segmentation. However, a unique feature in the procedure is the use of a fractional volume model that has been developed to provide a quantitative measure for the partial volume effect. With this model, the fractional constituent tissue volumes are evaluated for voxels at the tissue boundary that manifest partial volume effect, thus allowing tissue boundaries be defined at a sub-voxel level and in an automated fashion. Validation studies are presented on key algorithms including segmentation and registration. An overall assessment of the method is provided through the evaluation of the rates of brain atrophy in a group of normal elderly subjects for which the rate of brain atrophy due to normal aging is predictably small. An application of the method is given in Part 11 where the rates of brain atrophy in various brain regions are studied in relation to normal aging and Alzheimer's disease. (C) 2002 Elsevier Science Inc. All rights reserved.
Keyword Radiology, Nuclear Medicine & Medical Imaging
Structural Magnetic Resonance Imaging
Rate Of Volumetric Change
Rate Of Brain Atrophy
Partial Volume Effect
Normal Aging
Magnetic-resonance Images
Tissue Classification
Intensity Nonuniformity
Automatic Correction
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 19 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 04:39:38 EST