Design and utilisation of protocols to characterise dynamic PET uptake of two tracers using basis pursuit

Bell, Christopher, Puttick, Simon, Rose, Stephen, Smith, Jye, Thomas, Paul and Dowson, Nicholas (2017) Design and utilisation of protocols to characterise dynamic PET uptake of two tracers using basis pursuit. Physics in Medicine and Biology, 62 12: 4897-4916. doi:10.1088/1361-6560/aa6b44


Author Bell, Christopher
Puttick, Simon
Rose, Stephen
Smith, Jye
Thomas, Paul
Dowson, Nicholas
Title Design and utilisation of protocols to characterise dynamic PET uptake of two tracers using basis pursuit
Journal name Physics in Medicine and Biology   Check publisher's open access policy
ISSN 0031-9155
1361-6560
Publication date 2017-06-01
Year available 2017
Sub-type Article (original research)
DOI 10.1088/1361-6560/aa6b44
Open Access Status Not yet assessed
Volume 62
Issue 12
Start page 4897
End page 4916
Total pages 20
Place of publication Bristol, United Kingdom
Publisher Institute of Physics Publishing
Language eng
Abstract Imaging using more than one biological process using PET could be of great utility, but despite previously proposed approaches to dual-tracer imaging, it is seldom performed. The alternative of performing multiple scans is often infeasible for clinical practice or even in research studies. Dual-tracer PET scanning allows for multiple PET radiotracers to be imaged within the same imaging session. In this paper we describe our approach to utilise the basis pursuit method to aid in the design of dual-tracer PET imaging experiments, and later in separation of the signals. The advantage of this approach is that it does not require a compartment model architecture to be specified or even that both signals are distinguishable in all cases. This means the method for separating dual-tracer signals can be used for many feasible and useful combinations of biology or radiotracer, once an appropriate scanning protocol has been decided upon.
Formatted abstract
Imaging using more than one biological process using PET could be of great utility, but despite previously proposed approaches to dual-tracer imaging, it is seldom performed. The alternative of performing multiple scans is often infeasible for clinical practice or even in research studies. Dual-tracer PET scanning allows for multiple PET radiotracers to be imaged within the same imaging session. In this paper we describe our approach to utilise the basis pursuit method to aid in the design of dual-tracer PET imaging experiments, and later in separation of the signals. The advantage of this approach is that it does not require a compartment model architecture to be specified or even that both signals are distinguishable in all cases. This means the method for separating dual-tracer signals can be used for many feasible and useful combinations of biology or radiotracer, once an appropriate scanning protocol has been decided upon.

Following a demonstration in separating the signals from two consecutively injected radionuclides in a controlled experiment, phantom and list-mode mouse experiments demonstrated the ability to test the feasibility of dual-tracer imaging protocols for multiple injection delays. Increases in variances predicted for kinetic macro-parameters V D and K I in brain and tumoral tissue were obtained when separating the synthetically combined data. These experiments confirmed previous work using other approaches that injections delays of 10–20 min ensured increases in variance were kept minimal for the test tracers used. On this basis, an actual dual-tracer experiment using a 20 min delay was performed using these radio tracers, with the kinetic parameters (VD and KI) extracted for each tracer in agreement with the literature.

This study supports previous work that dual-tracer PET imaging can be accomplished provided certain constraints are adhered to. The utilisation of basis pursuit techniques, with its removed need to specify a model architecture, allows the feasibility of a range of imaging protocols to be investigated via simulation in a straight-forward manner for a wide range of possible scenarios. The hope is that the ease of utilising this approach during feasibility studies and in practice removes any perceived technical barrier to performing dual-tracer imaging.
Keyword PET
Basis pursuit
Dual-tracer
18F-FDOPA
18F-FDG
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 631567
R14/2173
Institutional Status UQ

 
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