Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C

Hickman, I. J., Clouston, A. D.., Macdonald, G. A., Purdie, D. M., Prins, J. B., Ash, S., Jonsson, J. R. and Powell, E. E. (2002) Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C. Gut, 51 1: 89-94. doi:10.1136/gut.51.1.89

Author Hickman, I. J.
Clouston, A. D..
Macdonald, G. A.
Purdie, D. M.
Prins, J. B.
Ash, S.
Jonsson, J. R.
Powell, E. E.
Title Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C
Journal name Gut   Check publisher's open access policy
ISSN 0017-5749
Publication date 2002-01-01
Year available 2002
Sub-type Article (original research)
DOI 10.1136/gut.51.1.89
Open Access Status Not yet assessed
Volume 51
Issue 1
Start page 89
End page 94
Total pages 6
Editor M. Farthing
Place of publication United Kingdom
Publisher B M J Publishing Group
Language eng
Subject C1
321006 Gastroenterology and Hepatology
730113 Digestive system and disorders
Abstract Background: Steatosis occurs in more than 50% of patients with chronic hepatitis C and is associated with increased hepatic fibrosis. In many of these patients the pathogenesis of steatosis appears to be the some as for patients with non-alcoholic fatty liver disease-that is, related to visceral adiposity and obesity. Methods: The effect of a three month weight reduction programme on liver biochemistry and metabolic parameters was examined in 19 subjects with steatosis and chronic hepatitis C. Paired liver biopsies were performed in 10 subjects, prior to and 3-6 months following the intervention, to determine the effect of weight loss on liver histology. Results: There was a mean weight loss of 5.9 (3.2) kg and a mean reduction in waist circumference of 9.0 (5.0) cm. In 16 of the 19 patients, serum alanine aminotransferase levels fell progressively with weight loss. Mean fasting insulin fell from 16 (7) to 11 (4) mmol/l (p<0.002). Nine of 10 patients with paired liver biopsies had a reduction in steatosis irrespective of viral genotype. In these subjects the median modified Knodell fibrosis score decreased from 3 to 1 (p=0.04) and activated stellate cells significantly decreased (p<0.004). Conclusions: Weight loss in patients with chronic hepatitis C may be associated with a reduction in steatosis and abnormal liver enzymes and an improvement in fibrosis, despite the persistence of the virus. Weight reduction may provide an important adjunct treatment strategy for patients with chronic hepatitis C.
Keyword Gastroenterology & Hepatology
Stellate Cell Activation
Body-mass Index
Uncoupling Protein-2
Waist Circumference
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Created: Wed, 15 Aug 2007, 04:29:26 EST