Exploring privileged structures: the combinatorial synthesis of cyclic peptides

Horton, D. A., Bourne, G. T. and Smythe, M. L. (2002) Exploring privileged structures: the combinatorial synthesis of cyclic peptides. Journal of Computer-aided Molecular Design, 16 5-6: 415-431. doi:10.1023/A:1020863921840


Author Horton, D. A.
Bourne, G. T.
Smythe, M. L.
Title Exploring privileged structures: the combinatorial synthesis of cyclic peptides
Journal name Journal of Computer-aided Molecular Design   Check publisher's open access policy
ISSN 0920-654X
1573-4951
Publication date 2002-05-01
Year available 2002
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1023/A:1020863921840
Volume 16
Issue 5-6
Start page 415
End page 431
Total pages 16
Editor Terry R. Stouch
Andrew R. Leach
Federico Gago
Place of publication Netherlands
Publisher Kluwer Academic Publishing
Language eng
Subject C1
250302 Biological and Medical Chemistry
780103 Chemical sciences
Abstract Head-to-tail cyclic peptides have been reported to bind to multiple, unrelated classes of receptor with high affinity. They may therefore be considered to be privileged structures. This review outlines the strategies by which both macrocyclic cyclic peptides and cyclic dipeptides or diketopiperazines have been synthesised in combinatorial libraries. It also briefly outlines some of the biological applications of these molecules, thereby justifying their inclusion as privileged structures.
Keyword Biochemistry & Molecular Biology
Biophysics
Computer Science, Interdisciplinary Applications
Combinatorial Chemistry
Cyclic Peptide
Diketopiperazine
Library Synthesis
Piperazine-2,5-dione
Privileged Structure
Ring Contraction
Solid-phase
Solid-phase-synthesis
Safety-catch Linker
Side-chain Attachment
Reverse-turn Peptidomimetics
Final Deprotection Strategy
Backbone Amide Linker
Polymer-bound Oxime
To-tail Cyclization
Beta-d-glucose
Conformational-analysis
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 15 Aug 2007, 04:23:08 EST