Working memory correlates of three symptom clusters in schizophrenia

Cameron, AM, Oram, J, Geffen, GM, Kavanagh, DJ, McGrath, JJ and Geffen, LB (2002) Working memory correlates of three symptom clusters in schizophrenia. Psychiatry Research, 110 1: 49-61. doi:10.1016/S0165-1781(02)00036-7


Author Cameron, AM
Oram, J
Geffen, GM
Kavanagh, DJ
McGrath, JJ
Geffen, LB
Title Working memory correlates of three symptom clusters in schizophrenia
Journal name Psychiatry Research   Check publisher's open access policy
ISSN 0165-1781
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1016/S0165-1781(02)00036-7
Volume 110
Issue 1
Start page 49
End page 61
Total pages 13
Editor M S Buchsbaum
Place of publication Ireland
Publisher Elsevier
Collection year 2002
Language eng
Subject C1
380103 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
780108 Behavioural and cognitive sciences
Abstract This study was designed to examine whether discrete working memory deficits underlie positive, negative and disorganised symptoms of schizophrenia. Symptom dimension ratings were assigned to 52 outpatients with schizophrenia (ICD-10 criteria), using items drawn from the Positive and Negative Syndrome Scale (PANSS). Linear regression and correlational analyses were conducted to examine whether symptom dimension scores were related to performance on several tests of working memory function. Severity of negative symptoms correlated with reduced production of words during a verbal fluency task, impaired ability to hold letter and number sequences on-line and manipulate them Simultaneously, reduced performance during a dual task, and compromised visuospatial working memory under distraction-free conditions. Severity of disorganisation symptoms correlated with impaired visuospatial working memory under conditions of distraction, failure of inhibition during a verbal fluency task, perseverative responding on a test of set-shifting ability, and impaired ability to judge the veracity of simple declarative statements. Severity of positive symptoms was uncorrelated with performance on any of the measures examined. The present study provides evidence that the positive, negative and disorganised symptom dimensions of the PANSS constitute independent clusters, associated with unique patterns of working memory impairment. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Keyword Psychiatry
Positive And Negative Syndrome Scale
Cognitive Function
Symptom Dimensions
Negative Syndrome Scale
Card Sorting Test
Frontal-lobe
Thought-disorder
Blood-flow
Panss
Dysfunction
Validation
Deficits
Model
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Psychology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 49 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 04:15:36 EST