FADS gene polymorphisms, fatty acid desaturase activities, and HDL-C in type 2 diabetes

Huang, Meng-Chuan, Chang, Wen-Tsan, Chang, Hsin-Yu, Chung, Hsin-Fang, Chen, Fang-Pei, Huang, Ya-Fang, Hsu, Chih-Cheng and Hwang, Shang-Jyh (2017) FADS gene polymorphisms, fatty acid desaturase activities, and HDL-C in type 2 diabetes. International Journal of Environmental Research and Public Health, 14 6: 572. doi:10.3390/ijerph14060572

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Author Huang, Meng-Chuan
Chang, Wen-Tsan
Chang, Hsin-Yu
Chung, Hsin-Fang
Chen, Fang-Pei
Huang, Ya-Fang
Hsu, Chih-Cheng
Hwang, Shang-Jyh
Title FADS gene polymorphisms, fatty acid desaturase activities, and HDL-C in type 2 diabetes
Formatted title
FADS gene polymorphisms, fatty acid desaturase activities, and HDL-C in type 2 diabetes
Journal name International Journal of Environmental Research and Public Health   Check publisher's open access policy
ISSN 1660-4601
1661-7827
Publication date 2017-05-28
Sub-type Article (original research)
DOI 10.3390/ijerph14060572
Open Access Status DOI
Volume 14
Issue 6
Start page 572
Total pages 11
Place of publication Basel, Switzerland
Publisher M D P I AG
Language eng
Subject 2739 Public Health, Environmental and Occupational Health
2307 Health, Toxicology and Mutagenesis
Abstract Polyunsaturated fatty acids (PUFA) correlate with risk of dyslipidemia and cardiovascular diseases. Fatty acid desaturase (FADS) single nucleotide polymorphisms (SNPs) modulate circulating PUFA concentrations. This study examined influence of FADS1 and FADS2 genetic variants on desaturase activities and blood lipid concentrations in type 2 diabetes patients, and further assessed their interrelationships. Selected SNPs (FADS1: rs174547, rs174548, rs174550; FADS2: rs174575, rs174576, rs174583, rs498793 and rs2727270) were genotyped in 820 type 2 diabetes patients and compared with those reported in the HapMap. Patient subgroups (n = 176) without taking lipid-lowering medicine were studied to assess influence of tag SNPs including rs174547, rs174575, rs498793 and rs2727270 on delta-5 desaturase (D5D: 20:4 (n-6)/20:3 (n-6)) and delta-6 desaturase (D6D:18:3 (n-6)/18:2 (n-6)) activities, and blood lipids. FADS1 rs174547 TT/TC/CC and FADS2 rs2727270 CC/CT/TT were significantly (p for trend < 0.05) associated with reduced HDL-C, D5D and D6D activities. Upon adjustment for confounders, D5D (p = 0.006) correlated significantly and D6D marginally (p = 0.07) correlated with increased HDL-C levels, whereas rs174547 and rs2727270 polymorphisms were not associated. D6D andD5D activities may play a role in modulating HDL-C levels in type 2 diabetes. Future studies with larger sample sizes are needed to investigate how FADS genetic variations interact with desaturase activities or PUFAs in the metabolism of lipoproteins in diabetic patients.
Formatted abstract
Polyunsaturated fatty acids (PUFA) correlate with risk of dyslipidemia and cardiovascular diseases. Fatty acid desaturase (FADS) single nucleotide polymorphisms (SNPs) modulate circulating PUFA concentrations. This study examined influence of FADS1 and FADS2 genetic variants on desaturase activities and blood lipid concentrations in type 2 diabetes patients, and further assessed their interrelationships. Selected SNPs (FADS1: rs174547, rs174548, rs174550; FADS2: rs174575, rs174576, rs174583, rs498793 and rs2727270) were genotyped in 820 type 2 diabetes patients and compared with those reported in the HapMap. Patient subgroups (n = 176) without taking lipid-lowering medicine were studied to assess influence of tag SNPs including rs174547, rs174575, rs498793 and rs2727270 on delta-5 desaturase (D5D: 20:4 (n-6)/20:3 (n-6)) and delta-6 desaturase (D6D:18:3 (n-6)/18:2 (n-6)) activities, and blood lipids. FADS1 rs174547 TT/TC/CC and FADS2 rs2727270 CC/CT/TT were significantly (p for trend < 0.05) associated with reduced HDL-C, D5D and D6D activities. Upon adjustment for confounders, D5D (p = 0.006) correlated significantly and D6D marginally (p = 0.07) correlated with increased HDL-C levels, whereas rs174547 and rs2727270 polymorphisms were not associated. D6D andD5D activities may play a role in modulating HDL-C levels in type 2 diabetes. Future studies with larger sample sizes are needed to investigate how FADS genetic variations interact with desaturase activities or PUFAs in the metabolism of lipoproteins in diabetic patients.
Keyword Diabetes
FADS1
FADS2
HDL
Genetic polymorphisms
Polyunsaturated fatty acids
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID NCT00288678
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Tue, 13 Jun 2017, 11:58:46 EST by Hsin-Fang Chung on behalf of School of Public Health