Mitochondrial complex II: at the crossroads

Bezawork-Geleta, Ayenachew, Rohlena, Jakub, Dong, Lanfeng, Pacak, Karel and Neuzil, Jiri (2017) Mitochondrial complex II: at the crossroads. Trends in Biochemical Sciences, 42 4: 312-325. doi:10.1016/j.tibs.2017.01.003

Author Bezawork-Geleta, Ayenachew
Rohlena, Jakub
Dong, Lanfeng
Pacak, Karel
Neuzil, Jiri
Title Mitochondrial complex II: at the crossroads
Journal name Trends in Biochemical Sciences   Check publisher's open access policy
ISSN 1362-4326
Publication date 2017-04-01
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tibs.2017.01.003
Open Access Status Not yet assessed
Volume 42
Issue 4
Start page 312
End page 325
Total pages 14
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central purveyor of the reprogramming of metabolic and respiratory adaptation in response to various intrinsic and extrinsic stimuli and abnormalities. In this review we discuss recent findings regarding SDH biogenesis, which requires four known assembly factors, and modulation of its enzymatic activity by acetylation, succinylation, phosphorylation, and proteolysis. We further focus on the emerging role of both genetic and epigenetic aberrations leading to SDH dysfunction associated with various clinical manifestations. This review also covers the recent discovery of the role of SDH in inflammation-linked pathologies. Conceivably, SDH is a potential target for several hard-to-treat conditions, including cancer, that remains to be fully exploited.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
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Created: Mon, 12 Jun 2017, 09:51:37 EST by Kirstie Asmussen on behalf of Queensland Brain Institute