Cisplatin-induced ototoxicity and pharmacokinetics: Preliminary findings in a dog model

Sockalingam, R., Filippich, L. J., Charles, B. G. and Murdoch, B. E. (2002) Cisplatin-induced ototoxicity and pharmacokinetics: Preliminary findings in a dog model. Annals of Otology, Rhinology and Laryngology, 111 8: 745-750.

Author Sockalingam, R.
Filippich, L. J.
Charles, B. G.
Murdoch, B. E.
Title Cisplatin-induced ototoxicity and pharmacokinetics: Preliminary findings in a dog model
Journal name Annals of Otology, Rhinology and Laryngology   Check publisher's open access policy
ISSN 0003-4894
Publication date 2002-01-01
Year available 2002
Sub-type Article (original research)
Volume 111
Issue 8
Start page 745
End page 750
Total pages 6
Place of publication Thousand Oaks, CA United States
Publisher Sage Publications Inc
Language eng
Subject C1
300512 Pharmacology
780105 Biological sciences
Abstract The early effects of clinical dose of cisplatin (100 mg/m(2)) on distort ion-product otoacoustic emissions (DPOAE) thresholds and the relationship between DPOAE threshold shifts and changes in plasma concentrations of filterable and total platinum (Pt) following infusion of cisplatin in a dog model were investigated. The DPOAE thresholds (based on input-output function) were measured 2 days before a single high dose of cisplatin administration, and compared with measurements recorded 2 and 4 days after infusion. The results revealed DPOAE thresholds to be elevated by 4 days after the administration of cisplatin. However, this elevation could not be correlated with plasma concentrations of filterable and total Pt, which showed little variation over the 48-hour postinfusion period between animals. The present study demonstrated that DPOAE thresholds have the potential to be used as an indicator of cisplatin-induced ototoxicity, and cisplatin-induced ototoxicity could not be explained by plasma Pt kinetics in individual animals.
Keyword Otorhinolaryngology
Cisplatin
Distortion-product Otoacoustic Emissions
Otoacoustic Emissions
Ototoxicity
Pharmacokinetics
Evoked Otoacoustic Emissions
Brain-stem Response
Guinea-pigs
Hearing-loss
Audiometry
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Health and Rehabilitation Sciences Publications
 
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Created: Wed, 15 Aug 2007, 04:05:50 EST