Impact of MRI markers in subcortical vascular dementia: a multi-modal analysis in CADASIL

Viswanathan, Anand, Godin, Ophelia, Jouvent, Eric, O'Sullivan, Michael, Gschwendtner, Andreas, Peters, Nils, Duering, Marco, Guichard, Jean-Pierre, Holtmannspoetter, Markus, Dufouil, Carole, Pachai, Chahin, Bousser, Marie-Germaine, Dichgans, Martin and Chabriat, Hugues (2010) Impact of MRI markers in subcortical vascular dementia: a multi-modal analysis in CADASIL. Neurobiology of Aging, 31 9: 1629-1636. doi:10.1016/j.neurobiolaging.2008.09.001

Author Viswanathan, Anand
Godin, Ophelia
Jouvent, Eric
O'Sullivan, Michael
Gschwendtner, Andreas
Peters, Nils
Duering, Marco
Guichard, Jean-Pierre
Holtmannspoetter, Markus
Dufouil, Carole
Pachai, Chahin
Bousser, Marie-Germaine
Dichgans, Martin
Chabriat, Hugues
Title Impact of MRI markers in subcortical vascular dementia: a multi-modal analysis in CADASIL
Journal name Neurobiology of Aging   Check publisher's open access policy
ISSN 0197-4580
Publication date 2010-09-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.neurobiolaging.2008.09.001
Open Access Status Not yet assessed
Volume 31
Issue 9
Start page 1629
End page 1636
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Abstract CADASIL is an arteriopathy caused by mutations of the Notch3 gene. White matter hyperintensities (WMH), lacunar lesions (LL), cerebral microhemorrhages (CM), brain atrophy and tissue microstructural changes are detected on MRI. Using an integrated multi-modal approach, we examined the relative impact of lesion burden and location of these MRI markers on cognitive impairment and disability. Multi-modal imaging was performed on 147 patients from a two-center cohort study. Volume of LL, WMH and number of CM was determined. Whole brain mean apparent diffusion coefficient (mean-ADC) and brain parenchymal fraction (BPF) were measured. In multivariate models accounting for lesion burden and location, volume of LL, mean-ADC, and BPF each had an independent influence on global cognitive function and disability. BPF explained the largest portion of the variation in cognitive and disability scores (35-38%). Brain atrophy has the strongest independent influence on clinical impairment in CADASIL when all MRI markers in the disease are considered together. The results suggest that the clinical impact of cerebral tissue loss plays a principal role in this genetic model of subcortical ischemic vascular dementia.
Keyword Atrophy
Cerebral microhemorrhage
Cognitive impairment
Lacunar infarction
White matter damage
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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