Enrichment increases hippocampal neurogenesis independent of blood monocyte-derived microglia presence following high-dose total body irradiation

Ruitenberg, Marc J., Wells, Julia, Bartlett, Perry F., Harvey, Alan R. and Vukovic, Jana (2017) Enrichment increases hippocampal neurogenesis independent of blood monocyte-derived microglia presence following high-dose total body irradiation. Brain Research Bulletin, 132 150-159. doi:10.1016/j.brainresbull.2017.05.013

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Author Ruitenberg, Marc J.
Wells, Julia
Bartlett, Perry F.
Harvey, Alan R.
Vukovic, Jana
Title Enrichment increases hippocampal neurogenesis independent of blood monocyte-derived microglia presence following high-dose total body irradiation
Journal name Brain Research Bulletin   Check publisher's open access policy
ISSN 0361-9230
1873-2747
Publication date 2017-06-01
Sub-type Article (original research)
DOI 10.1016/j.brainresbull.2017.05.013
Open Access Status File (Author Post-print)
Volume 132
Start page 150
End page 159
Total pages 10
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
Birth of new neurons in the hippocampus persists in the brain of adult mammals and critically underpins optimal learning and memory. The process of adult neurogenesis is significantly reduced following brain irradiation and this correlates with impaired cognitive function. In this study, we aimed to compare the long-term effects of two environmental paradigms (i.e. enriched environment and exercise) on adult neurogenesis following high-dose (10 Gy) total body irradiation. When housed in standard (sedentary) conditions, irradiated mice revealed a long-lasting (up to at least 4 months) deficit in neurogenesis in the granule cell layer of the dentate gyrus, the region that harbors the neurogenic niche. This depressive effect of total body irradiation on adult neurogenesis was partially alleviated by exposure to enriched environment but not voluntary exercise, where mice were single-housed with unlimited access to a running wheel. Exposure to voluntary exercise, but not enriched environment, did lead to significant increases in microglia density in the granule cell layer of the hippocampus; our study shows that these changes result from local microglia proliferation rather than recruitment and infiltration of circulating Cx3cr1+/gfp blood monocytes that subsequently differentiate into microglia-like cells. In summary, latent neural precursor cells remain present in the neurogenic niche of the adult hippocampus up to at least 8 weeks following high-dose total body irradiation. Environmental enrichment can partially restore the adult neurogenic process in this part of the brain following high-dose irradiation, and this was found to be independent of blood monocyte-derived microglia presence.
Keyword Enriched environment
Microglia
Irradiation
Bone marrow chimera
Exercise
Running
Q-Index Code C1
Institutional Status UQ

 
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Created: Thu, 08 Jun 2017, 13:42:59 EST by Jana Vukovic on behalf of School of Biomedical Sciences