Vascular dysfunction and heart failure: Epiphenomenon or etiologic agent?

Fang, ZY and Marwick, TH (2002) Vascular dysfunction and heart failure: Epiphenomenon or etiologic agent?. American Heart Journal, 143 3: 383-390. doi:10.1067/mhj.2002.120780

Author Fang, ZY
Marwick, TH
Title Vascular dysfunction and heart failure: Epiphenomenon or etiologic agent?
Journal name American Heart Journal   Check publisher's open access policy
ISSN 0002-8703
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1067/mhj.2002.120780
Volume 143
Issue 3
Start page 383
End page 390
Total pages 8
Editor Robert M Califf
Daniel B Mark
Place of publication USA
Publisher Mosby Inc
Language eng
Subject C1
321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
Abstract Endothelial function plays a key role in the local regulation of vascular tone. Alterations in endothelial function may result in impaired release of endothelium-derived relaxing factors or increased release of endothelium-derived contracting factors. Heart failure may impair endothelial function by means of reduced synthesis and release of nitric oxide (NO) or by increased degradation of NO and increased production of endothelin-1. Endothelial dysfunction may worsen heart function by means of peripheral effects, causing increased afterload and central effects such as myocardial ischemia and inducible nitric oxide synthase (iNOS)-induced detrimental effects. Evidence from clinical studies has suggested that there is a correlation between decreased endothelial function and increasing severity of congestive heart failure (CHF). Treatments that improve heart function may also improve endothelial dysfunction. The relationship between endothelial dysfunction and heart failure may be masked by the stage of endothelial dysfunction, the location of vessels being tested, and the state of endothelial-dependent vasodilatation response.
Keyword Cardiac & Cardiovascular Systems
Nitric-oxide Synthase
Endothelium-dependent Dilation
Relaxing Factor
Cardiac Myocytes
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Created: Wed, 15 Aug 2007, 03:44:09 EST