Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model

Dunn, Haley C., Ager, Rahasson R., Baglietto-Vargas, David, Cheng, David, Kitazawa, Masashi, Cribbs, David H. and Medeiros, Rodrigo (2015) Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. Journal of Alzheimers Disease, 43 3: 893-903. doi:10.3233/JAD-141335


Author Dunn, Haley C.
Ager, Rahasson R.
Baglietto-Vargas, David
Cheng, David
Kitazawa, Masashi
Cribbs, David H.
Medeiros, Rodrigo
Title Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model
Journal name Journal of Alzheimers Disease   Check publisher's open access policy
ISSN 1875-8908
1387-2877
Publication date 2015-01-01
Sub-type Article (original research)
DOI 10.3233/JAD-141335
Open Access Status Not yet assessed
Volume 43
Issue 3
Start page 893
End page 903
Total pages 11
Place of publication Amsterdam, Netherlands
Publisher IOS Press
Language eng
Formatted abstract
The initiation of an inflammatory response is critical to the survival of an organism. However, when inflammation fails to reach resolution, a chronic inflammatory state may occur, potentially leading to bystander tissue damage. Accumulating evidence suggests that chronic inflammation contributes to the progression of Alzheimer's disease (AD), and identifying mechanisms to resolve the pro-inflammatory environment stimulated by AD pathology remains an area of active investigation. Previously, we found that treatment with the pro-resolving mediator aspirin-triggered lipoxin A4 (ATL), improved cognition, reduced Aβ levels, and enhanced microglia phagocytic activity in Tg2576 transgenic AD mice. Here, we evaluated the effect of aging on brain lipoxin A4 (LXA4) levels using non-transgenic and 3xTg-AD mice. Additionally, we investigated the effect of ATL treatment on tau pathology in 3xTg-AD mice. We found that LXA4 levels are reduced with age, a pattern significantly more impacted in 3xTg-AD mice. Moreover, ATL delivery enhanced the cognitive performance of 3xTg-AD mice and reduced Aβ levels, as well as decreased the levels of phosphorylated-tau (p-tau). The decrease in p-tau was due in part to an inhibition of the tau kinases GSK-3β and p38 MAPK. In addition, microglial and astrocyte reactivity was inhibited by ATL treatment. Our results suggest that the inability to resolve the immune response during aging might be an important feature that contributes to AD pathology and cognitive deficits. Furthermore, we demonstrate that activation of LXA4 signaling could serve as a potential therapeutic target for AD-related inflammation and cognitive dysfunction.
Keyword 3xTg-AD
Aging
Alzheimer's disease
Aspirin-triggered lipoxin A4
Inflammation
Lipoxin
Lipoxygenase
Resolution
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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