The role of tau in Alzheimer's disease and related disorders

Medeiros, Rodrigo, Baglietto-Vargas, David and LaFerla, Frank M. (2011) The role of tau in Alzheimer's disease and related disorders. CNS Neuroscience and Therapeutics, 17 5: 514-524. doi:10.1111/j.1755-5949.2010.00177.x

Author Medeiros, Rodrigo
Baglietto-Vargas, David
LaFerla, Frank M.
Title The role of tau in Alzheimer's disease and related disorders
Journal name CNS Neuroscience and Therapeutics   Check publisher's open access policy
ISSN 1755-5930
Publication date 2011-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1755-5949.2010.00177.x
Open Access Status Not yet assessed
Volume 17
Issue 5
Start page 514
End page 524
Total pages 11
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Tau, the microtubule-associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under physiological conditions, tau regulates the assembly and maintenance of the structural stability of microtubules. In the diseased brain, however, tau becomes abnormally hyperphosphorylated, which ultimately causes the microtubules to disassemble, and the free tau molecules aggregate into paired helical filaments. A large body of evidence suggests that tau hyperphosphorylation results from perturbation of cellular signaling, mainly through imbalance in the activities of different protein kinases and phosphatases. In AD, it appears that ß-amyloid peptide (Aß) plays a pivotal role in triggering this imbalance. In this review, we summarize our current understanding of the role of tau in AD and other tauopathies, and highlight key issues that need to be addressed to improve the success of developing novel therapies.
Keyword ß-Amyloid
Alzheimer's disease
Neurofibrillary tangles
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 40 times in Thomson Reuters Web of Science Article | Citations
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