Noninvasive measurement of cerebral bioimpedance for detection of cerebral edema in the neonatal piglet

Lingwood, Barbara E., Dunster, Kimble R., Colditz, Paul B. and Ward, Leigh C. (2002) Noninvasive measurement of cerebral bioimpedance for detection of cerebral edema in the neonatal piglet. Brain Research, 945 1: 97-105. doi:10.1016/S0006-8993(02)02744-0


Author Lingwood, Barbara E.
Dunster, Kimble R.
Colditz, Paul B.
Ward, Leigh C.
Title Noninvasive measurement of cerebral bioimpedance for detection of cerebral edema in the neonatal piglet
Journal name Brain Research   Check publisher's open access policy
ISSN 0006-8993
Publication date 2002-07-26
Sub-type Article (original research)
DOI 10.1016/S0006-8993(02)02744-0
Volume 945
Issue 1
Start page 97
End page 105
Total pages 9
Editor F. E. Bloom
Place of publication Amsterdam
Publisher Elsevier Science
Language eng
Subject C1
321019 Paediatrics
730104 Nervous system and disorders
Abstract The association of sustained cerebral edema with poor neurological outcome following hypoxia-ischaemia in the neonate suggests that measurement of cerebral edema may allow early prediction of outcome in these infants. Direct measurements of cerebral impedance have been widely used in animal studies to monitor cerebral edema, but such invasive measurements are not possible in the human neonate. This study investigated the ability of noninvasive cerebral impedance measurements to detect cerebral edema following hypoxia-ischaemia. One-day-old piglets were anaesthetized, intubated and ventilated. Hypoxia was induced by reducing the inspired oxygen concentration to 4-6% O-2. Noninvasive cerebral bioimpedance was measured using gel electrodes attached to the scalp. Cerebral bioimpedance was also measured directly by insertion of two silver-silver chloride electrodes subdurally. Noninvasive and invasive measurements were made before, during and after hypoxia. Whole body impedance was measured to assess overall fluid movements. Intracranial pressure was measured continuously via a catheter inserted subdurally, as an index of cerebral edema. There was good agreement between noninvasive and invasive measurements of cerebral impedance although externally obtained responses were attenuated. Noninvasive measurements were also well correlated with intracranial pressure. Whole body impedance changes did not account for increases in noninvasively measured cerebral impedance. Results suggest that noninvasive cerebral impedance measurements do reflect intracranial events, and are able to detect cerebral edema following hypoxia-ischaemia in the neonate. (C) 2002 Elsevier Science B.V. All rights reserved.
Keyword Neurosciences
Edema
Hypoxia
Impedance
Noninvasive
Bioelectrical-impedance Analysis
Total-body Water
Multiple Frequency Bioimpedance
Prediction
Ischemia
Brain
Damage
Rat
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 03:32:09 EST