The role of the Eph-ephrin signalling system in the regulation of developmental patterning

Coulthard, MG, Duffy, S, Down, M, Evans, B, Power, M, Smith, F, Stylianou, C, Kleikamp, S, Oates, A, Lackmann, M, Burns, GF and Boyd, AW (2002) The role of the Eph-ephrin signalling system in the regulation of developmental patterning. International Journal of Developmental Biology, 46 4: 375-384.


Author Coulthard, MG
Duffy, S
Down, M
Evans, B
Power, M
Smith, F
Stylianou, C
Kleikamp, S
Oates, A
Lackmann, M
Burns, GF
Boyd, AW
Title The role of the Eph-ephrin signalling system in the regulation of developmental patterning
Journal name International Journal of Developmental Biology   Check publisher's open access policy
ISSN 0214-6282
Publication date 2002-01-01
Year available 2002
Sub-type Critical review of research, literature review, critical commentary
Volume 46
Issue 4
Start page 375
End page 384
Total pages 10
Editor J. Arechaga
G. Eguchi et al.
Place of publication Bilbao, Spain
Publisher UBC Press
Language eng
Subject C1
321011 Medical Genetics
730107 Inherited diseases (incl. gene therapy)
Abstract The Eph and ephrin system, consisting of fourteen Eph receptor tyrosine kinase proteins and nine ephrin membrane proteins in vertebrates, has been implicated in the regulation of many critical events during development. Binding of cell surface Eph and ephrin proteins results in bi-directional signals, which regulate the cytoskeletal, adhesive and motile properties of the interacting cells. Through these signals Eph and ephrin proteins are involved in early embryonic cell movements, which establish the germ layers, cell movements involved in formation of tissue boundaries and the pathfinding of axons. This review focuses on two vertebrate models, the zebrafish and mouse, in which experimental perturbation of Eph and/or ephrin expression in vivo have provided important insights into the role and functioning of the Eph/ephrin system.
Keyword Developmental Biology
Eph Receptor
Ephrin
Signalling
Zebrafish
Mouse Knockout
Receptor Tyrosine Kinase
Neural Development
Ligand Ephrin-b2
Cell-adhesion
Cardiovascular Development
Retinotectal Projection
Vascular Morphogenesis
Corticospinal Tract
Cytoplasmic Domain
Boundary Formation
Q-Index Code C1
Institutional Status UQ
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 03:31:50 EST